ArticleBMC genetics2005
Examining the effect of linkage disequilibrium on multipoint linkage analysis.
Article in BMC genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Collapsed haplotype pattern method for linkage analysis of next-generation sequence data.European journal of human genetics : EJHG · 2015Article
- Adaptive introgression in an African malaria mosquito coincident with the increased usage of insecticide-treated bed nets.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Spatiotemporal dynamics of gene flow and hybrid fitness between the M and S forms of the malaria mosquito, Anopheles gambiae.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mapping a new spontaneous preterm birth susceptibility gene, IGF1R, using linkage, haplotype sharing, and association analysis.PLoS genetics · 2011Article
- Linkage analysis in the next-generation sequencing era.Human heredity · 2011Review
- Evaluation of approaches to identify associated SNPs that explain the linkage evidence in nuclear families with affected siblings.Human heredity · 2010Article
- Examining the effect of linkage disequilibrium between markers on the Type I error rate and power of nonparametric multipoint linkage analysis of two-generation and multigenerational pedigrees in the presence of missing genotype data.Genetic epidemiology · 2008Article
- Ignoring intermarker linkage disequilibrium induces false-positive evidence of linkage for consanguineous pedigrees when genotype data is missing for any pedigree member.Human heredity · 2008Article
- Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.American journal of human genetics · 2007Article
- The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports.BMC medical genetics · 2007Article
- The affected-/discordant-sib-pair design can guarantee validity of multipoint model-free linkage analysis of incomplete pedigrees when there is marker-marker disequilibrium.American journal of human genetics · 2006Article
- Multipoint identity-by-descent computations for single-point polymorphism and microsatellite maps.BMC genetics · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most linkage programs assume linkage equilibrium among multiple linked markers. This assumption may lead to bias for tightly linked markers where strong linkage disequilibrium (LD) exists. We used simulated data from Genetic Analysis Workshop 14 to examine the possible effect of LD on multipoint linkage analysis. Single-nucleotide polymorphism packets from a non-disease-related region that was generated with LD were used for both model-free and parametric linkage analyses. Results showed that high LD among markers can induce false-positive evidence of linkage for affected sib-pair analysis when parental data are missing. Bias can be eliminated with parental data and can be reduced when additional markers not in LD are included in the analyses.
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