ArticleBMC genetics2005
A genome-wide linkage and association study using COGA data.
Article in BMC genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Recent advances in genetic studies of alcohol use disorders.Current genetic medicine reports · 2020Article
- Genetic risk prediction and neurobiological understanding of alcoholism.Translational psychiatry · 2014Article
- ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior.Chinese medical journal · 2012Article
- Genome-wide association study of copy number variants suggests LTBP1 and FGD4 are important for alcohol drinking.PloS one · 2012Article
- Nonparametric Covariate-Adjusted Association Tests Based on the Generalized Kendall's Tau().Journal of the American Statistical Association · 2012Article
- Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study.Journal of neural transmission (Vienna, Austria : 1996) · 2011Article
- Statistical Analysis in Genetic Studies of Mental Illnesses.Statistical science : a review journal of the Institute of Mathematical Statistics · 2011Article
- An Association Test for Multiple Traits Based on the Generalized Kendall's Tau.Journal of the American Statistical Association · 2010Article
- ROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure.American journal of human genetics · 2010Article
- SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample.Genes, brain, and behavior · 2009Article
- Case-control association testing with related individuals: a more powerful quasi-likelihood score test.American journal of human genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundGenome-wide association will soon be available to use as an adjunct to traditional linkage analysis. We studied alcoholism in 119 families collected by the Collaborative Study on the Genetics of Alcoholism and made available in Genetic Analysis Workshop 14, using genome-wide linkage and association analyses.
methodsGenome-wide linkage analysis was first performed using microsatellite markers and a region with the strongest linkage evidence was further analyzed using single-nucleotide polymorphisms (SNPs). Family based genome-wide association test was also conducted using the SNPs.
resultsNonparametric linkage analysis revealed weak linkage evidence on chromosome 7, and association analysis identified SNP tsc0515272 on chromosome 3 as significantly associated with alcoholism.
conclusionLinkage analysis may require large sample sizes and high quality genotyping and marker maps to adequately improve power, while association analysis could hold more promise in efforts to identify variants responsible for complex traits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.