ArticleThe Biochemical journal2006
Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria.
Article in The Biochemical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- A lipidomics analysis of the relationship between dietary fatty acid composition and insulin sensitivity in young adults.Diabetes · 2013Trial
- Article
- Saccharomyces cerevisiae as a Model for Reprogramming of Eukaryotic Cells: Implications for the Study of the Relationship Between Metabolism and Inflammation in Chronic Disease.Cell biochemistry and biophysics · 2025Article
- Regulation of redox homeostasis by ATF4-MTHFD2 axis during white adipose tissue browning.Redox biology · 2025Article
- Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms.The Journal of biological chemistry · 2017Review
- Being right on Q: shaping eukaryotic evolution.The Biochemical journal · 2016Review
- Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart.Heart failure reviews · 2015Review
- How to deal with oxygen radicals stemming from mitochondrial fatty acid oxidation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Coenzyme Q10 depletion in medical and neuropsychiatric disorders: potential repercussions and therapeutic implications.Molecular neurobiology · 2013Review
- Fatty acids are key in 4-hydroxy-2-nonenal-mediated activation of uncoupling proteins 1 and 2.PloS one · 2013Article
- Fatty acids change the conformation of uncoupling protein 1 (UCP1).The Journal of biological chemistry · 2012Article
- Hydroxynonenal, a lipid peroxidation end product, stimulates uncoupling protein activity in Acanthamoeba castellanii mitochondria; the sensitivity of the inducible activity to purine nucleotides depends on the membranous ubiquinone redox state.Journal of bioenergetics and biomembranes · 2012Article
- Relationship of electrophilic stress to aging.Free radical biology & medicine · 2011Review
- Test systems to study the structure and function of uncoupling protein 1: a critical overview.Frontiers in endocrinology · 2011Article
- Not all mitochondrial carrier proteins support permeability transition pore formation: no involvement of uncoupling protein 1.Bioscience reports · 2009Article
- Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria.Journal of bioenergetics and biomembranes · 2009Article
- Effect of aging, caloric restriction, and uncoupling protein 3 (UCP3) on mitochondrial proton leak in mice.Experimental gerontology · 2008Article
- Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria.The Biochemical journal · 2008Article
- Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential.Bioscience reports · 2008Article
- Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The kinetics of proton transport through mammalian UCP1 (uncoupling protein 1) expressed in yeast mitochondria were measured. There was little or no UCP1 activity in the absence of added palmitate, but significant activity in its presence. The activator 4-HNE (4-hydroxy-2-nonenal) had little effect when added alone, but significantly enhanced proton conductance in the presence of added palmitate. Activation of the proton conductance of UCP1 was synergistic: proton conductance in the presence of both palmitate and 4-HNE was significantly greater than the sum of the individual effects. Mitochondria from control yeast transformed with empty vector showed no such synergy, showing that synergy is a property of UCP1. Activation by the 4-HNE analogue trans-cinnamate showed essentially the same characteristics as activation by 4-HNE. Mitochondria from brown adipose tissue also showed synergistic activation of GDP-sensitive proton conductance by palmitate and 4-HNE. These results show that reactive alkenals activate the proton conductance of UCP1 more strongly when fatty acids are also added, with implications for both mechanistic and physiological models of UCP1 activation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.