ReviewClinical cardiology2005
Epidemiology and stratification of risk for sudden cardiac death.
Review in Clinical cardiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Cardiac sympathetic hyperinnervation after myocardial infarction: a systematic review and qualitative analysis.Annals of medicine · 2023Pooled it
- Failing hearts are more vulnerable to dobutamine and caffeine-induced ventricular arrhythmias: Ameliorated with dantrolene treatment.Heart rhythm O2 · 2025Article
- Comparison of hypothermic and normothermic targeted temperature management in out-of-hospital cardiac arrest patients with acute coronary syndrome: a nationwide retrospective study.Critical care (London, England) · 2025Article
- Obesity Arrhythmias: Role of IL-6 Trans-Signaling.International journal of molecular sciences · 2024Review
- Metabolic and electrolyte abnormalities as risk factors in drug-induced long QT syndrome.Biophysical reviews · 2022Review
- Optimal Indicator of Death for Using Real-World Cancer Patients' Data From the Healthcare System.Frontiers in pharmacology · 2022Article
- Discussing the Score of Cardioembolic Ischemic Stroke in Chagas Disease.Tropical medicine and infectious disease · 2020Article
- Enhancement of β-catenin/T-cell factor 4 signaling causes susceptibility to cardiac arrhythmia by suppressing NaHeart rhythm · 2019Article
- Enhancing Autophagy Diminishes Aberrant CaFrontiers in physiology · 2019Article
- Anterior pericardial access to facilitate electrophysiology study and catheter ablation of ventricular arrhythmias: A single tertiary center experience.Journal of cardiovascular electrophysiology · 2017Article
- Review
- Electrophysiological alterations in a murine model of chronic coxsackievirus B3 myocarditis.PloS one · 2017Article
- Arrhythmias in the Heart Transplant Patient.Arrhythmia & electrophysiology review · 2014Article
- Mechanisms underlying the autonomic modulation of ventricular fibrillation initiation--tentative prophylactic properties of vagus nerve stimulation on malignant arrhythmias in heart failure.Heart failure reviews · 2013Review
- Sudden cardiac death in the young: how can disease recognition and prevention in family members be improved?Herzschrittmachertherapie & Elektrophysiologie · 2012Article
- Long QT2 mutation on the Kv11.1 ion channel inhibits current activity by ablating a protein kinase Cα consensus site.Molecular pharmacology · 2012Article
- Common variation in fatty acid genes and resuscitation from sudden cardiac arrest.Circulation. Cardiovascular genetics · 2012Article
- A novel, minimally invasive, segmental myocardial infarction with a clear healed infarct borderzone in rabbits.American journal of physiology. Heart and circulatory physiology · 2012Article
- Primary outcomes for resuscitation science studies: a consensus statement from the American Heart Association.Circulation · 2011Article
- Synergism between arrhythmia and hyperhomo-cysteinemia in structural heart disease.International journal of physiology, pathophysiology and pharmacology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sudden cardiac death (SCD) is a major cause of mortality in the United States. Approximately 65% of cases of SCD occur in patients with underlying acute or chronic ischemic heart disease. The incidence of SCD increases 2- to 4-fold in the presence of coronary disease and 6- to 10-fold in the presence of structural heart disease. Ventricular fibrillation (VF) precipitated by ventricular tachycardia (VT) is a common mechanism of cardiac arrest leading to SCD. Triggers for SCD include electrolyte disturbances, heart failure, and transient ischemia. Although a large percentage of patients with out-of-hospital SCD do not survive, successful resuscitation to hospitalization has improved in recent years. One of the challenges for preventing SCD lies in identifying individuals at highest risk for SCD within a lower-risk population. The progression from conventional risk factors of coronary artery disease to arrhythmogenesis and SCD can be represented as a cascade of changes associated with levels of increasing risk. At the first level is atherogenesis, followed by changes in atherosclerotic plaque anatomy, which may be mediated by inflammatory processes. Disruption of active plaque formed during a transitional state initiates the thrombotic cascade and acute occlusion, after which acute changes in myocardial electrophysiology become the immediate trigger for arrhythmogenesis and SCD. Each level of the cascade offers different opportunities for risk prediction. Among the classes of risk predictors are clinical markers, such as ECG measures and ejection fraction. Transient risk markers, such as inflammatory markers, are potentially useful for identifying triggers for SCD. In the future, genetic profiling is expected to allow better assessment of individual risks for SCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.