Evidence map›Paper›PMID 16450057›Full record

ReviewJournal of muscle research and cell motility2006

Global and local control of microtubule destabilization promoted by a catastrophe kinesin MCAK/XKCM1.

Kazuhisa Kinoshita, Tim L Noetzel, Isabelle Arnal, David N Drechsel, Anthony A Hyman

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of muscle research and cell motility, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Role of APC and its binding partners in regulating microtubules in mitosis.Advances in experimental medicine and biology · 2009
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kazuhisa KinoshitaMax Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Pfotenhauerstrasse 108, 01307, Dresden, Germany. kinoshita@mpi-cbg.de
Tim L Noetzel
Isabelle Arnal
David N Drechsel
Anthony A Hyman

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditionally, kinesins have been identified as proteins that use the energy of ATP to translocate along microtubules. However, in the last decade some kinesin-like proteins were found to destabilize microtubule ends. The kinesins that destabilize microtubules are known as "catastrophe kinesins". Analyses of a Xenopus member of the catastrophe kinesins called MCAK/XKCM1 have shown that, in fact, catastrophe kinesins are essential for controlling the distribution of microtubules by inducing their depolymerization. Therefore, unraveling the mechanisms of how microtubule destabilization promoted by these catastrophe kinesins is controlled is essential for understanding how microtubules in a cell are distributed. Here we give an overview of the studies that have focused on the global and local control of microtubule destabilization promoted by MCAK/XKCM1.

Indexed as

Adenosine TriphosphateAnimalsHumansKinesinsMicrotubulesProtein TransportXenopusXenopus ProteinsAdenosine TriphosphateKIF11 protein, XenopusKIF2C protein, humanKinesinsXenopus Proteins

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.