ArticleOncogene2006
Execution of BMP-4-induced apoptosis by p53-dependent ER dysfunction in myeloma and B-cell hybridoma cells.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Enhanced BMP Signaling Alters Human β-Cell Identity and Function.Advanced biology · 2025Article
- P53 Activated by ER Stress Aggravates Caerulein-Induced Acute Pancreatitis Progression by Inducing Acinar Cell Apoptosis.Digestive diseases and sciences · 2020Article
- The ferroptosis inducer erastin promotes proliferation and differentiation in human peripheral blood mononuclear cells.Biochemical and biophysical research communications · 2018Article
- Quercetin suppresses DNA double-strand break repair and enhances the radiosensitivity of human ovarian cancer cells via p53-dependent endoplasmic reticulum stress pathway.OncoTargets and therapy · 2018Article
- Article
- Utilizing BMP-2 muteins for treatment of multiple myeloma.PloS one · 2017Article
- PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud.Development (Cambridge, England) · 2016Article
- Augmented BMP signaling in the neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis.Development (Cambridge, England) · 2015Article
- Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenoma.Molecular and cellular endocrinology · 2014Review
- Gene and microRNA expression reveals sensitivity to paclitaxel in laryngeal cancer cell line.International journal of clinical and experimental pathology · 2013Article
- Bone morphogenetic protein-2 and -4 play tumor suppressive roles in human diffuse-type gastric carcinoma.The American journal of pathology · 2011Article
- Different doses of bone morphogenetic protein 4 promote the expression of early germ cell-specific gene in bone marrow mesenchymal stem cells.In vitro cellular & developmental biology. Animal · 2011Article
- The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice.Developmental biology · 2011Article
- Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells.International journal of biological sciences · 2010Article
- Embryonic expression of cyclooxygenase-2 causes malformations in axial skeleton.The Journal of biological chemistry · 2010Article
- Iron-dependent regulation of MDM2 influences p53 activity and hepatic carcinogenesis.The American journal of pathology · 2010Article
- Article
- Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis.Oncogene · 2008Article
- A human bone morphogenetic protein antagonist is down-regulated in renal cancer.Molecular biology of the cell · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone morphogenic protein (BMP)-4 inhibits proliferation and induces the apoptosis of myeloma cells. However, little is known about the molecular mechanisms of how BMP-4 executes this apoptosis. In this report, we investigated the roles of p53 and the endoplasmic reticulum (ER) in BMP-4-induced apoptosis of mouse hybridoma HS-72 cells. We found that 3 ng/ml of BMP-4 is sufficient to induce the expression of proapoptotic proteins, puma and bax, in a p53-dependent mechanism, and facilitate Ca(2+) release from the ER to the cytosol, resulting in the activation of caspase-12 and ER dysfunction. Similarly to HS-72 cells, multiple myeloma cells with wild-type p53 genes show much higher sensitivity to BMP-4-induced apoptosis than cells without wild-type p53 genes, suggesting that wild-type p53 status is required for dysfunction of the ER during BMP-4-induced apoptosis in ER-enriched cells, such as hybridoma and myeloma cells. These findings demonstrate that the presence of wild-type p53 genes and enrichment of the ER determines the sensitivity to effective apoptosis by BMP-4, and suggest that ER stress-inducing agents would be valuable in the treatment of multiple myeloma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.