ArticleMolecular and cellular biology2006
AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- New Frontiers for the Cytoskeletal Protein LASP1.Frontiers in oncology · 2018Review
- Selective activator protein-1 inhibitor T-5224 prevents lymph node metastasis in an oral cancer model.Cancer science · 2016Article
- An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein.Oncotarget · 2015Review
- Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated Ubiquitination as an Alternate Pathway to Myofibrillar Disruption in Nemaline Myopathy.American journal of human genetics · 2013Article
- Inhibition of α-SMA by the ectodomain of FGFR2c attenuates lung fibrosis.Molecular medicine (Cambridge, Mass.) · 2012Article
- Role of hepatitis B virus X protein in regulating LIM and SH3 protein 1 (LASP-1) expression to mediate proliferation and migration of hepatoma cells.Virology journal · 2012Article
- BTB-Kelch protein Krp1 regulates proliferation and differentiation of myoblasts.American journal of physiology. Cell physiology · 2011Article
- Scaffolds and chaperones in myofibril assembly: putting the striations in striated muscle.Biophysical reviews · 2011Article
- EPS8 upregulates FOXM1 expression, enhancing cell growth and motility.Carcinogenesis · 2010Article
- Subcellular localization of Mayven following expression of wild type and mutant EGFP tagged cDNAs.BMC neuroscience · 2010Article
- Article
- Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension.The Journal of biological chemistry · 2009Article
- Lasp1 gene disruption is linked to enhanced cell migration and tumor formation.Physiological genomics · 2009Article
- Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments.The Journal of cell biology · 2008Article
- Targeted disruption of the Lasp-1 gene is linked to increases in histamine-stimulated gastric HCl secretion.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- The LIM and SH3 domain protein family: structural proteins or signal transducers or both?Molecular cancer · 2008Article
- Krp1 (Sarcosin) promotes lateral fusion of myofibril assembly intermediates in cultured mouse cardiomyocytes.Experimental cell research · 2008Article
- Nuclear localization and cytosolic overexpression of LASP-1 correlates with tumor size and nodal-positivity of human breast carcinoma.BMC cancer · 2007Article
- Overexpression of LASP-1 mediates migration and proliferation of human ovarian cancer cells and influences zyxin localisation.British journal of cancer · 2007Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor AP-1, which is composed of Fos and Jun family proteins, plays an essential role in tumor cell invasion by altering gene expression. We report here that Krp1, the AP-1 up-regulated protein that has a role in pseudopodial elongation in v-Fos-transformed rat fibroblast cells, forms a novel interaction with the nondifferentially expressed actin binding protein Lasp-1. Krp1 and Lasp-1 colocalize with actin at the tips of pseudopodia, and this localization is maintained by continued AP-1 mediated down-regulation of fibronectin that in turn suppresses integrin and Rho-ROCK signaling and allows pseudopodial protrusion and mesenchyme-like invasion. Mutation analysis of Lasp-1 demonstrates that its SH3 domain is necessary for pseudopodial extension and invasion. The results support the concept of an AP-1-regulated multigenic invasion program in which proteins encoded by differentially expressed genes direct the function, localization, and activity of proteins that are not differentially expressed to enhance the invasiveness of cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.