ArticleMolecular and cellular biology2006
Chromatin decondensation and nuclear reprogramming by nucleoplasmin.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 119 citations in OpenAlex.
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- Maternal effect factors that contribute to oocytes developmental competence: an update.Journal of assisted reproduction and genetics · 2022Review
- Cell division- and DNA replication-free reprogramming of somatic nuclei for embryonic transcription.iScience · 2021Article
- All roads lead to Rome: the many ways to pluripotency.Journal of assisted reproduction and genetics · 2020Review
- Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy.Acta neuropathologica · 2020Article
- Dimerization of MORC2 through its C-terminal coiled-coil domain enhances chromatin dynamics and promotes DNA repair.Cell communication and signaling : CCS · 2019Article
- New tools for cell reprogramming and conversion: Possible applications to livestock.Animal reproduction · 2019Article
- Structural insights into the ability of nucleoplasmin to assemble and chaperone histone octamers for DNA deposition.Scientific reports · 2019Article
- Mechanical principles of nuclear shaping and positioning.The Journal of cell biology · 2018Review
- Histone H3.3 sub-variant H3mm7 is required for normal skeletal muscle regeneration.Nature communications · 2018Article
- Fatal familial insomnia: mitochondrial and protein synthesis machinery decline in the mediodorsal thalamus.Brain pathology (Zurich, Switzerland) · 2017Article
- RE1-silencing Transcription Factor (REST) Is Required for Nuclear Reprogramming by Inhibiting Transforming Growth Factor β Signaling Pathway.The Journal of biological chemistry · 2016Article
- Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome.Brain pathology (Zurich, Switzerland) · 2016Article
- H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells.Stem cell reports · 2016Article
- The quest for an effective and safe personalized cell therapy using epigenetic tools.Clinical epigenetics · 2016Review
- Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson's disease.Acta neuropathologica communications · 2015Article
- The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins.Journal of molecular biology · 2015Article
- Developmentally Regulated Post-translational Modification of Nucleoplasmin Controls Histone Sequestration and Deposition.Cell reports · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Somatic cell nuclear cloning has repeatedly demonstrated striking reversibility of epigenetic regulation of cell differentiation. Upon injection into eggs, the donor nuclei exhibit global chromatin decondensation, which might contribute to reprogramming the nuclei by derepressing dormant genes. Decondensation of sperm chromatin in eggs is explained by the replacement of sperm-specific histone variants with egg-type histones by the egg protein nucleoplasmin (Npm). However, little is known about the mechanisms of chromatin decondensation in somatic nuclei that do not contain condensation-specific histone variants. Here we found that Npm could widely decondense chromatin in undifferentiated mouse cells without overt histone exchanges but with specific epigenetic modifications that are relevant to open chromatin structure. These modifications included nucleus-wide multiple histone H3 phosphorylation, acetylation of Lys 14 in histone H3, and release of heterochromatin proteins HP1beta and TIF1beta from the nuclei. The protein kinase inhibitor staurosporine inhibited chromatin decondensation and these epigenetic modifications with the exception of H3 acetylation, potentially linking these chromatin events. At the functional level, Npm pretreatment of mouse nuclei facilitated activation of four oocyte-specific genes from the nuclei injected into Xenopus laevis oocytes. Future molecular elucidation of chromatin decondensation by Npm will significantly contribute to our understanding of the plasticity of cell differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.