ArticleMolecular and cellular biology2006
Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- LncRNA H19 promoted alcohol-associated liver disease through dysregulation of alternative splicing and methionine metabolism.Hepatology (Baltimore, Md.) · 2025Article
- DysregulatedeLife · 2022Article
- DNA methylation of insulin-like growth factor 2 and H19 cluster in cord blood and prenatal air pollution exposure to fine particulate matter.Environmental health : a global access science source · 2020Article
- Cyclic Strain PromotesCellular and molecular bioengineering · 2020Article
- Modeling human epigenetic disorders in mice: Beckwith-Wiedemann syndrome and Silver-Russell syndrome.Disease models & mechanisms · 2020Review
- Hemimethylation of CpG dyads is characteristic of secondary DMRs associated with imprinted loci and correlates with 5-hydroxymethylcytosine at paternally methylated sequences.Epigenetics & chromatin · 2019Article
- LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat.Nature communications · 2018Article
- Tissue-specific and mosaic imprinting defects underlie opposite congenital growth disorders in mice.PLoS genetics · 2018Article
- Lipid metabolism is associated with developmental epigenetic programming.Scientific reports · 2016Article
- H19ICR mediated transcriptional silencing does not require target promoter methylation.Biochemical and biophysical research communications · 2016Article
- Visualizing allele-specific expression in single cells reveals epigenetic mosaicism in an H19 loss-of-imprinting mutant.Genes & development · 2016Article
- Mouse models of adrenocortical tumors.Molecular and cellular endocrinology · 2016Review
- Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations.Clinical epigenetics · 2016Article
- Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.European journal of nutrition · 2015Article
- Bisphenol a exposure disrupts metabolic health across multiple generations in the mouse.Endocrinology · 2015Article
- Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.Human molecular genetics · 2014Article
- Epigenetic regulation of the Igf2/H19 gene cluster.Cell proliferation · 2014Review
- Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence.Nature · 2013Article
- Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin.The American journal of pathology · 2012Article
- Temporal and developmental requirements for the Prader-Willi imprinting center.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The differentially methylated domain (DMD) of the mouse H19 gene is a methylation-sensitive insulator that blocks access of the Igf2 gene to shared enhancers on the maternal allele and inactivates H19 expression on the methylated paternal allele. By analyzing H19 DMD deletion alleles H19DeltaDMD and H19Delta3.8kb-5'H19 in pre- and postimplantation embryos, we show that the DMD exhibits positive transcriptional activity and is required for H19 expression in blastocysts and full activation of H19 during subsequent development. We also show that the DMD is required to establish Igf2 imprinting by blocking access to shared enhancers when Igf2 monoallelic expression is initiated in postimplantation embryos and that the single remaining CTCF site of the H19DeltaDMD allele is unable to provide this function. Furthermore, our data demonstrate that sequence outside of the DMD can attract some paternal-allele-specific CpG methylation 5' of H19 in preimplantation embryos, although this methylation is not maintained during postimplantation in the absence of the DMD. Finally, we report a conditional allele floxing the 1.6-kb sequence deleted from the H19DeltaDMD allele and demonstrate that the DMD is required to maintain repression of the maternal Igf2 allele and the full activity of the paternal Igf2 allele in neonatal liver.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.