ArticleMolecular and cellular biology2006
Cyclic AMP inhibits p38 activation via CREB-induced dynein light chain.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
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- Fluoroquinolones Suppress TGF-β and PMA-Induced MMP-9 Production in Cancer Cells: Implications in Repurposing Quinolone Antibiotics for Cancer Treatment.International journal of molecular sciences · 2021Article
- Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines.Mediators of inflammation · 2018Article
- Prostaglandin E2 inhibits α-smooth muscle actin transcription during myofibroblast differentiation via distinct mechanisms of modulation of serum response factor and myocardin-related transcription factor-A.The Journal of biological chemistry · 2014Article
- Calcitonin gene-related peptide regulates type IV hypersensitivity through dendritic cell functions.PloS one · 2014Article
- Protective effect of survivin in Doxorubicin-induced cell death in h9c2 cardiac myocytes.Korean circulation journal · 2013Article
- Chronic psychological stress induces the accumulation of myeloid-derived suppressor cells in mice.PloS one · 2013Article
- Nocodazole increases the ERK activity to enhance MKP-1expression which inhibits p38 activation induced by TNF-α.Molecular and cellular biochemistry · 2012Article
- Unconventional functions of microtubule motors.Archives of biochemistry and biophysics · 2012Review
- Lethality in a murine model of pulmonary anthrax is reduced by combining nuclear transport modifier with antimicrobial therapy.PloS one · 2012Article
- Cyclic AMP: a selective modulator of NF-κB action.Cellular and molecular life sciences : CMLS · 2011Review
- Differential roles of PKA and Epac on the production of cytokines in the endotoxin-stimulated primary cultured microglia.Journal of molecular neuroscience : MN · 2011Article
- Toll-like receptors and signalling in spermatogenesis and testicular responses to inflammation--a perspective.Journal of reproductive immunology · 2011Article
- Activation of p38 mitogen-activated protein kinase by norepinephrine in T-lineage cells.Immunology · 2011Article
- Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase.Journal of the American Society of Nephrology : JASN · 2010Article
- Elevated cAMP opposes (TNF-alpha)-induced loss in the barrier integrity of corneal endothelium.Molecular vision · 2010Article
- Adenosine receptor A2A deficiency in leukocytes increases arterial neointima formation in apolipoprotein E-deficient mice.Arteriosclerosis, thrombosis, and vascular biology · 2010Article
- Farnesol induces hydrogen peroxide resistance in Candida albicans yeast by inhibiting the Ras-cyclic AMP signaling pathway.Eukaryotic cell · 2010Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The mitogen-activated protein kinase p38 plays a critical role in inflammation, cell cycle progression, differentiation, and apoptosis. The activity of p38 is stimulated by a variety of extracellular stimuli, such as the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha), and subjected to regulation by other intracellular signaling pathways, including the cyclic AMP (cAMP) pathway. Yet the underlying mechanism by which cAMP inhibits p38 activation is unknown. Here we show that the induction of dynein light chain (DLC) by cAMP response element-binding protein (CREB) is required for cAMP-mediated inhibition of p38 activation. cAMP inhibits p38 activation via the protein kinase A-CREB pathway. The inhibition is mediated by the CREB target gene Dlc, whose protein product, DLC, interferes with the formation of the MKK3/6-p38 complex, thereby suppressing p38 phosphorylation activation by MKK3/6. The inhibition of p38 activation by cAMP leads to suppression of NF-kappaB activity and promotion of apoptosis in response to TNF-alpha. Thus, our results identify DLC as a novel inhibitor of the p38 pathway and provide a molecular mechanism by which cAMP suppresses p38 activation and promotes apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.