ArticleBlood2006
Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms.
Article in Blood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Pre-TCR-targeted immunotherapy for T cell acute lymphoblastic leukemia.Nature immunology · 2025Article
- Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T-ALL.Leukemia · 2024Article
- CDK6 is essential for mesenchymal stem cell proliferation and adipocyte differentiation.Frontiers in molecular biosciences · 2023Article
- E Protein Transcription Factors as Suppressors of T Lymphocyte Acute Lymphoblastic Leukemia.Frontiers in immunology · 2022Review
- MonoallelicFrontiers in immunology · 2022Article
- Oncogenic and Tumor Suppressor Functions for Lymphoid Enhancer Factor 1 inFrontiers in immunology · 2022Article
- Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells.Frontiers of medicine · 2018Review
- Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Targeting the Notch signaling pathway in cancer therapeutics.Thoracic cancer · 2014Review
- Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts.Haematologica · 2014Article
- Article
- Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic mice.PloS one · 2012Article
- Article
- Genomic loss of the putative tumor suppressor gene E2A in human lymphoma.The Journal of experimental medicine · 2011Article
- Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.The Journal of pathology · 2011Review
- Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis.Immunity · 2010Article
- Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model.Cancer science · 2009Article
- Hes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genes.PloS one · 2009Article
- Article
- E and ID proteins branch out.Nature reviews. Immunology · 2009Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Loss of E2A transcription factor activity or activation of the intracellular form of Notch1 (ICN) leads to the development of leukemia or lymphoma in humans or mice, respectively. Current models propose that ICN functions by suppressing E2A through a pre-T cell receptor (TCR)-dependent mechanism. Here we show that lymphomas arising in E2A(-/-) mice require the activation of Notch1 for their survival and have accumulated mutations in, or near, the Notch1 PEST domain, resulting in increased stability and signaling. In contrast, lymphomas arising in p53(-/-) mice show the activation of Notch1, but no mutations were identified in ICN. The requirement for Notch1 signaling in E2A(-/-) lymphomas cannot be overcome by ectopic expression of pTalpha; however, pTalpha is required for optimal survival and expansion of these cells. Our findings indicate that the activation of Notch1 is an important "second hit" for the transformation of E2A(-/-) T cell lymphomas and that Notch1 promotes survival through pre-TCR-dependent and -independent mechanisms.
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Registered trials
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