ArticleArchives of disease in childhood2006
Beta-cell autoantibodies in children with type 2 diabetes mellitus: subgroup or misclassification?
Article in Archives of disease in childhood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Pathophysiology of Type 2 Diabetes in Children and Adolescents.Current diabetes reviews · 2020Pooled it
- Double or hybrid diabetes: A systematic review on disease prevalence, characteristics and risk factors.Nutrition & diabetes · 2019Pooled it
- Utility of the random C-peptide and random C-peptide index at diagnosis as a predictor of disease type and long-term insulin secretory capacity in children with diabetes mellitus.Endocrine journal · 2025Article
- Latent autoimmune diabetes in youth.Frontiers in immunology · 2025Review
- Are Prediction Models Moving Closer to Clinical Application in the Diagnosis of Type of Diabetes in Youth?Diabetes care · 2024Article
- Trends in endogenous insulin secretion capacity and anti-islet autoantibody titers in two childhood-onset slowly progressive insulin-dependent diabetes mellitus cases.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2024Article
- Article
- Prevalence of type 2 diabetes mellitus in the pediatric population of a third-level care hospital in Mexico City in 2013 and 2018.World journal of diabetes · 2023Article
- Thyroid autoantibody distribution in patients with latent autoimmune diabetes in youth: a multicenter, national survey.Annals of translational medicine · 2022Article
- The epidemiology, clinical, biochemical, immunological and radiological features of youth onset type 2 diabetes mellitus in the state of Qatar.Diabetology international · 2022Article
- Autoimmune reaction against pancreatic beta cells in children and adolescents with simple obesity.Frontiers in endocrinology · 2022Observational
- Type 2 Diabetes Mellitus in a 7 Year Old Girl.International medical case reports journal · 2022Article
- Clinical Characteristics of Patients WithFrontiers in endocrinology · 2022Review
- Diagnosis, treatment and prevention of type 2 diabetes mellitus in children and adolescents.World journal of diabetes · 2021Review
- Incidence of Type 2 Diabetes in Kuwaiti Children and Adolescents: Results From the Childhood-Onset Diabetes Electronic Registry (CODeR).Frontiers in endocrinology · 2019Article
- Understanding childhood diabetes mellitus: new pathophysiological aspects.Journal of inherited metabolic disease · 2018Review
- Double diabetes in Saudi Arabia: A new entity or an underestimated condition.World journal of diabetes · 2016Article
- An efficient approach for surveillance of childhood diabetes by type derived from electronic health record data: the SEARCH for Diabetes in Youth Study.Journal of the American Medical Informatics Association : JAMIA · 2016Article
- Utility of diabetes-associated autoantibodies for classification of new onset diabetes in children and adolescents.Pediatric diabetes · 2016Article
- Obesity and youth diabetes: distinguishing characteristics between islet cell antibody positive vs. negative patients over time.Pediatric diabetes · 2015Article
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6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn adults, a fraction of diabetic individuals with beta-cell autoantibodies has initially non-insulin requiring diabetes clinically appearing as type 2 diabetes mellitus (T2DM), named latent autoimmune diabetes in adulthood (LADA). The occurrence of beta-cell autoantibodies in European children and adolescents with T2DM has not been reported so far.
methodsThe frequency of beta-cell autoantibodies (anti-GAD, anti-IA-2, and anti-ICA) was determined in 7050 diabetic children and adolescents. The type of diabetes was classified by paediatric diabetic specialists based on the clinical presentation. Children with non-insulin dependent T2DM over a one year period were studied separately.
resultsA total of 6922 children were clinically classified as having type 1 diabetes (T1DM) and 128 children as having T2DM. Thirty six per cent of the children with T2DM had at least one detectable beta-cell autoantibody. These children did not differ significantly from the children with T2DM and without autoantibodies in respect of age, gender, weight status, lipids, blood pressure, C-peptide, glucose, and HbA1c at manifestation, as well as frequency of anti-thyroidal antibodies and insulin treatment during follow up. In the subgroup of the 38 children with T2DM without insulin requirement over a one year period, autoantibodies occurred in 32%. These 12 children were predominantly obese (67%), female (67%), and in the pubertal age range.
conclusionbeta-cell autoantibodies were detectable in a subgroup of initially non-insulin dependent diabetic children and adolescents with the clinical appearance of T2DM. Following the terminology "latent autoimmune diabetes in adulthood (LADA)", this subgroup might be classified as "LADY" (latent autoimmune diabetes in youth).
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