ArticleBiophysical journal2006
Polynucleotide adsorption to negatively charged surfaces in divalent salt solutions.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- CoNanoscale · 2025Article
- SILEX: a fast and inexpensive high-quality DNA extraction method suitable for multiple sequencing platforms and recalcitrant plant species.Plant methods · 2020Article
- Direct visualization of the native structure of viroid RNAs at single-molecule resolution by atomic force microscopy.RNA biology · 2019Article
- The role of macromolecules in the formation of kidney stones.Urolithiasis · 2017Review
- Aptamer Microarrays-Current Status and Future Prospects.Microarrays (Basel, Switzerland) · 2015Review
- Study of DNA adsorption on mica surfaces using a surface force apparatus.Scientific reports · 2015Article
- A magnesium-induced RNA conformational switch at the internal ribosome entry site of hepatitis C virus genome visualized by atomic force microscopy.Nucleic acids research · 2015Article
- Tunable soft structure in charged fluids confined by dielectric interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Imaging of nucleic acids with atomic force microscopy.Methods (San Diego, Calif.) · 2011Review
- Localized nanoscopic surface measurements of nickel-modified mica for single-molecule DNA sequence sampling.ACS applied materials & interfaces · 2010Article
- A self-assembly pathway to aligned monodomain gels.Nature materials · 2010Article
- Electrostatic and hydrophobic interactions involved in CNT biofunctionalization with short ss-DNA.The journal of physical chemistry. C, Nanomaterials and interfaces · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Polynucleotide adsorption to negatively charged surfaces via divalent ions is extensively used in the study of biological systems. We analyze here the adsorption mechanism via a self-consistent mean-field model that includes the pH effect on the surface-charge density and the interactions between divalent ions and surface groups. The adsorption is driven by the cooperative effect of divalent metal ion condensation along polynucleotides and their reaction with the surface groups. Although the apparent reaction constants are enhanced by the presence of polynucleotides, the difference between reaction constants of different divalent ions at the ideal condition explains why not all divalent cations mediate DNA adsorption onto anionic surfaces. Calculated divalent salt concentration and pH value variations on polynucleotide adsorption are consistent with atomic force microscope results. Here we use long-period x-ray standing waves to study the adsorption of mercurated-polyuridylic acid in a ZnCl2 aqueous solution onto a negatively charged hydroxyl-terminated silica surface. These in situ x-ray measurements, which simultaneously reveal the Hg and Zn distribution profiles along the surface normal direction, are in good agreement with our model. The model also provides the effects of polyelectrolyte line-charge density and monovalent salt on adsorption.
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Registered trials
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