ArticleThe Journal of cell biology2006
Asynchronous nuclear division cycles in multinucleated cells.
Article in The Journal of cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
74 citing papers in PubMed, 129 citations in OpenAlex.
- Arrest of nuclear division in Plasmodium through blockage of erythrocyte surface exposed ribosomal protein P2.PLoS pathogens · 2012Trial
- Competitive resource allocation drives asynchronous and rapid nuclear multiplication in the malaria parasite.Nature communications · 2026Article
- A phase oscillator model of cell cycles reveals nuclear density control in a branched fungal network.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- RNA-specific local translation is patterned by condensates for multinucleate cell growth.Nature cell biology · 2026Article
- Mechanisms of nuclear segregation in a multinucleate multibudding yeast.The Journal of cell biology · 2025Article
- RNA encodes physical information.bioRxiv : the preprint server for biology · 2024Article
- Intrinsically disordered sequences can tune fungal growth and the cell cycle for specific temperatures.Current biology : CB · 2024Article
- Origins of cancer: ain't it just mature cells misbehaving?The EMBO journal · 2024Review
- Mitigating transcription noise via protein sharing in syncytial cells.Biophysical journal · 2024Article
- Syncytial Assembly Lines: Consequences of Multinucleate Cellular Compartments for Fungal Protein Synthesis.Results and problems in cell differentiation · 2024Review
- Aspergillus SUMOylation mutants exhibit chromosome segregation defects including chromatin bridges.Genetics · 2023Article
- Article
- High-content analysis of testicular toxicity of BPA and its selected analogs in mouse spermatogonial, Sertoli cells, and Leydig cells revealed BPAF induced unique multinucleation phenotype associated with the increased DNA synthesis.Toxicology in vitro : an international journal published in association with BIBRA · 2023Article
- Plasmodium schizogony, a chronology of the parasite's cell cycle in the blood stage.PLoS pathogens · 2023Review
- Postmitotic centriole disengagement and maturation leads to centrosome amplification in polyploid trophoblast giant cells.Molecular biology of the cell · 2022Article
- PRD-2 mediates clock-regulated perinuclear localization of clock gene RNAs within the circadian cycle ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Asynchronous nuclear cycles in multinucleatedScience advances · 2022Article
- Communal living: the role of polyploidy and syncytia in tissue biology.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2021Review
- Skeletal muscle fibers count on nuclear numbers for growth.Seminars in cell & developmental biology · 2021Review
- Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synchronous mitosis is common in multinucleated cells. We analyzed a unique asynchronous nuclear division cycle in a multinucleated filamentous fungus, Ashbya gossypii. Nuclear pedigree analysis and observation of GFP-labeled spindle pole bodies demonstrated that neighboring nuclei in A. gossypii cells are in different cell cycle stages despite close physical proximity. Neighboring nuclei did not differ significantly in their patterns of cyclin protein localization such that both G1 and mitotic cyclins were present regardless of cell cycle stage, suggesting that the complete destruction of cyclins is not occurring in this system. Indeed, the expression of mitotic cyclin lacking NH(2)-terminal destruction box sequences did not block cell cycle progression. Cells lacking AgSic1p, a predicted cyclin-dependent kinase (CDK) inhibitor, however, showed aberrant multipolar spindles and fragmented nuclei that are indicative of flawed mitoses. We hypothesize that the continuous cytoplasm in these cells promoted the evolution of a nuclear division cycle in which CDK inhibitors primarily control CDK activity rather than oscillating mitotic cyclin proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.