ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2006
Detection of the new human coronavirus HKU1: a report of 6 cases.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 1 of them a synthesis that pooled it.
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106 citing papers in PubMed, 1 synthesis or guideline pooled it, 200 citations in OpenAlex.
- The COVID-19 pandemic in a paediatric population: A health care perspective.Journal of mother and child · 2022Pooled it
- Trial
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- Enteric nervous system as a target and source of SARS-CoV-2 and other viral infections.American journal of physiology. Gastrointestinal and liver physiology · 2023Review
- Association between the Seroprevalence of Antibodies against Seasonal Alphacoronaviruses and SARS-CoV-2 Humoral Immune Response, COVID-19 Severity, and Influenza Vaccination.Journal of clinical medicine · 2023Article
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- A Mouse-Adapted Model of HCoV-OC43 and Its Usage to the Evaluation of Antiviral Drugs.Frontiers in microbiology · 2022Article
- Gastrointestinal manifestations in COVID-19.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2021Review
- COVID-19 in Ophthalmology. Current Disease Status and Challenges during Clinical Practice.Maedica · 2021Article
- Antiviral performance of graphene-based materials with emphasis on COVID-19: A review.Medicine in drug discovery · 2021Review
- Development and application of a method to detect 27 respiratory pathogens using multiplex RT-PCR combined with MassARRAY technology.BMC infectious diseases · 2021Article
- SARS-CoV-2 receptor-binding mutations and antibody contact sites.Antibody therapeutics · 2021Article
- First Detection ofActa medica Lituanic · 2021Article
- Estimating the duration of seropositivity of human seasonal coronaviruses using seroprevalence studies.Wellcome open research · 2021Article
46 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman coronavirus HKU1 (HCoV-HKU1), a new group 2 coronavirus, was first characterized in 2005 from 2 adults with pneumonia in Hong Kong, China. To the best of our knowledge, there is no other report to date about the detection of this new virus. We report a molecular method allowing for the detection of HCoV-HKU1 and also report the clinical presentation of 6 infected patients.
methodsWe screened 141 specimens (135 nasal samples and 6 stool samples) received in February and March 2005 in our laboratory and obtained from 135 hospitalized patients (61.5% of whom were <5 years old and 34.1% of whom were >20 years old) for HCoV-HKU1.
resultsHCoV-HKU1 was detected in 6 (4.4%) of the 135 nasal specimens and in 2 (33.3%) of the 6 stool samples; the positive samples were obtained from 6 patients (5 children and 1 adult). The clinical presentation of these 6 patients was as follows: 3 were admitted to the hospital for acute enteric disease resulting in severe dehydration associated with upper respiratory symptoms; 1 had fever, otitis, and febrile seizure; 1 had a sample obtained to investigate failure to thrive; and 1 had a sample obtained for exploration of X-linked agammaglobulinemia and hyperleucocytosis.
conclusionHCoV-HKU1 can be detected in respiratory and stool samples from children and adults in a part of the world other than Hong Kong. Our results suggest that HCoV-HKU1 could be associated with respiratory and enteric diseases, and its detection can be related to a persistent asymptomatic infection in patients with poor underlying conditions.
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