ArticleParasitology research2006
A newborn mouse Cryptosporidium parvum infection model: its application to the study of therapeutic and prophylactic measures for controlling cryptosporidiosis in ruminants.
Article in Parasitology research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 12 citations in OpenAlex.
- Delivery of SA35 and SA40 peptides in mice enhances humoral and cellular immune responses and confers protection against Cryptosporidium parvum infection.Parasites & vectors · 2019Article
- Efficacy of pyrvinium pamoate against Cryptosporidium parvum infection in vitro and in a neonatal mouse model.Antimicrobial agents and chemotherapy · 2008Article
- Experimental study of the effects of probiotics on Cryptosporidium parvum infection in neonatal rats.Parasitology research · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, a newborn mouse model of Cryptosporidium parvum infection is presented so as to evaluate therapeutic and prophylactic measures for controlling cryptosporidiosis in ruminants. Ninety-six suckling mice from ten litters were used. The mice in group I were infected with C. parvum oocysts, and the mice in group II served as non-infected controls. In both groups, intensity of infection and serum IgG, IgA and IgM responses were measured at 6, 9, 12 and 16 days post-infection (pi). Experimentally induced infection in mice proved to be similar to natural infections in lambs, kids and calves. Thus, the intensity of infection peaked at 9 days pi then decreased slightly, showing its lowest value at 16 days pi. This decline in the number of oocysts coincided with peaks in IgM and IgA. Finally, non-infected mice had no oocysts and did not show any increase in their anti-C. parvum antibody levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.