ArticleHuman genetics2006
Genetic linkage of human height is confirmed to 9q22 and Xq24.
Article in Human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Analysis of the genetic basis of height in large Jewish nuclear families.PLoS genetics · 2019Article
- Older individuals heterozygous for a growth hormone-releasing hormone receptor gene mutation are shorter than normal subjects.Journal of human genetics · 2015Article
- Article
- Genes that escape X-inactivation in humans have high intraspecific variability in expression, are associated with mental impairment but are not slow evolving.Molecular biology and evolution · 2013Article
- Sex-specific genetic architecture of human fatness in Chinese: the SAPPHIRe Study.Human genetics · 2010Article
- A blue spectral shift of the hemoglobin soret band correlates with the age (time since deposition) of dried bloodstains.PloS one · 2010Article
- Linkage analysis of adult height in a large pedigree from a Dutch genetically isolated population.Human genetics · 2009Article
- Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci.Human genetics · 2009Article
- Extended haplotypes in the growth hormone releasing hormone receptor gene (GHRHR) are associated with normal variation in height.PloS one · 2009Article
- A large-scale genome-wide linkage analysis to map loci linked to stature in Chinese population.The Journal of clinical endocrinology and metabolism · 2008Article
- A genome-wide scan for quantitative trait loci affecting limb bone lengths and areal bone mineral density of the distal femur in a White Duroc x Erhualian F2 population.BMC genetics · 2008Article
- Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians.Human genetics · 2008Article
- Applying novel genome-wide linkage strategies to search for loci influencing type 2 diabetes and adult height in American Samoa.Human biology · 2008Article
- Family-based association study of ROR2 polymorphisms with an array of radiographic hand bone strength phenotypes.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2007Article
- Genome partitioning of genetic variation for height from 11,214 sibling pairs.American journal of human genetics · 2007Article
- Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci.PLoS genetics · 2007Article
- Comprehensive multi-stage linkage analyses identify a locus for adult height on chromosome 3p in a healthy Caucasian population.Human genetics · 2007Article
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13 authors.
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Abstract
Human height is an important and heritable trait. Our previous two genome-wide linkage studies using 630 (WG1 study) and an extended sample of 1,816 Caucasians (WG2 study) identified 9q22 [maximum LOD score (MLS)=2.74 in the WG2 study] and preliminarily confirmed Xq24 (two-point LOD score=1.91 in the WG1 study, 2.64 in the WG2 study) linked to height. Here, with a much further extended large sample containing 3,726 Caucasians, we performed a new genome-wide linkage scan and confirmed, in high significance, the two regions' linkage to height. An MLS of 4.34 was detected on 9q22 and a two-point LOD score of 5.63 was attained for Xq24. In an independent sub-sample (i.e., the subjects not involved in the WG1 and WG2 studies), the two regions also achieved significant empirical P values (0.002 and 0.004, respectively) for "region-wise" linkage confirmation. Importantly, the two regions were replicated on a genotyping platform different from the WG1 and WG2 studies (i.e., a different set of markers and different genotyping instruments). Interestingly, 9q22 harbors the ROR2 gene, which is required for growth plate development, and Xq24 was linked to short stature. With the largest sample from a single population of the same ethnicity in the field of linkage studies for complex traits, our current study, together with two previous ones, provided overwhelming evidence substantiating 9q22 and Xq24 for height variation. In particular, our three consecutive whole genome studies are uniquely valuable as they represent the first practical (rather than simulated) example of how significant increase in sample size may improve linkage detection for human complex traits.
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