ArticleMolecular vision2006
Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice.
Article in Molecular vision, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- [Epithelial-mesenchymal Transition: Biological Basis and Clinical Prospects of Lung Cancer Invasion, Metastasis, and Drug Resistance].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025Review
- The role of heparan sulphate in development: the ectodermal story.International journal of experimental pathology · 2016Review
- Dlg-1 Interacts With and Regulates the Activities of Fibroblast Growth Factor Receptors and EphA2 in the Mouse Lens.Investigative ophthalmology & visual science · 2016Article
- A gradient of matrix-bound FGF-2 and perlecan is available to lens epithelial cells.Experimental eye research · 2014Article
- Epithelial mesenchymal transition from a natural gestational orchestration to a bizarre cancer disturbance.Cancer science · 2013Review
- Mouse chimeras as a system to investigate development, cell and tissue function, disease mechanisms and organ regeneration.Cell cycle (Georgetown, Tex.) · 2011Review
- A missense mutation in Fgfr1 causes ear and skull defects in hush puppy mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Notch signaling is required for lateral induction of Jagged1 during FGF-induced lens fiber differentiation.Developmental biology · 2009Article
- The basics of epithelial-mesenchymal transition.The Journal of clinical investigation · 2009Review
- Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation.Developmental biology · 2008Article
- Cell cycle regulation in the developing lens.Seminars in cell & developmental biology · 2006Review
- An essential role for FGF receptor signaling in lens development.Seminars in cell & developmental biology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeThe developing lens expresses at least three different FGF receptor genes (Fgfr1, Fgfr2, Fgfr3). Furthermore, FGFs have been shown to induce lens epithelial cells to differentiate into fiber cells both in vitro and in vivo. While the loss of Fgfr2 alone does not prevent fiber differentiation and the loss of Fgfr3 alone does not appear to affect lens development, the independent role of Fgfr1 in lens development has not been reported. These experiments were conducted to determine if Fgfr1 plays an independent, essential role in lens development.
methodsTo address this question, we took two complementary approaches. First, we employed the aphakia (ak) lens complementation system to show that Fgfr1 deficient embryonic stem (ES) cells were able to form a normal embryonic lens that maintains a normal pattern of crystallin gene expression. Second, we employed the Cre-loxP system to achieve lens-specific inactivation of Fgfr1.
resultsFgfr1 null embryonic stem cells were able to rescue normal embryonic lens development in chimeric combination with aphakia mutant embryos. In addition, conditional deletion of Fgfr1 does not compromise lens development either before or after birth.
conclusionsThe results of both approaches suggest that lens epithelial cell integrity, cell cycle regulation and lens fiber differentiation are intact in the Fgfr1 deficient lens. Overall, our results demonstrate that Fgfr1 is not cell autonomously essential for lens development and suggests functional redundancy among different FGF receptor genes with respect to lens fiber differentiation.
Indexed as
Identifiers
16446698PMC4280232W328185343What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.