ArticleJapanese journal of cancer research : Gann1992
Differential expression of vinculin between weakly and highly metastatic B16-melanoma cell lines.
Article in Japanese journal of cancer research : Gann, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- High expression of Talin-1 is associated with tumor progression and recurrence in melanoma skin cancer patients.BMC cancer · 2023Article
- Complete Model of Vinculin Suggests the Mechanism of Activation by Helical Super-Bundle Unfurling.The protein journal · 2022Article
- Adhesion strength and anti-tumor agents regulate vinculin of breast cancer cells.Frontiers in oncology · 2022Article
- Combined Toxicity of Gas Plasma Treatment and Nanoparticles Exposure in Melanoma Cells In Vitro.Nanomaterials (Basel, Switzerland) · 2021Article
- Correlation of histopathologic characteristics to protein expression and function in malignant melanoma.PloS one · 2017Article
- New insights into vinculin function and regulation.International review of cell and molecular biology · 2011Review
- Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin.Journal of cell science · 2010Article
- Suppression of cancer phenotypes through a multifunctional actin-binding protein, calponin, that attacks cancer cells and simultaneously protects the host from invasion.Cancer science · 2005Review
- Article
- Inhibition of tumor cell haptotaxis by sodium D-glucaro-delta-lactam (ND2001).Japanese journal of cancer research : Gann · 1995Article
- Intracellular localization and biochemical function of variant beta-actin, which inhibits metastasis of B16 melanoma.Japanese journal of cancer research : Gann · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously reported on the altered expression of a third actin in mouse-B16 melanoma associated with malignant progression. While further investigating the relationship of cytoskeletal proteins to malignancy, we found that the expression of vinculin was higher in weakly metastatic B16-F1 cells than in highly metastatic B16-F10 cells. By Northern blot analysis, the mRNA expression of vinculin in B16-F1 was also shown to be higher than in B16-F10. Immunofluorescence staining showed a clear dotted distribution of vinculin in B16-F1, but only a weak and diffuse distribution in B16-F10. The dotted distribution tended to be larger in B16-F1 and when cultured on Matrigel and fibronectin than on laminin and type IV collagen. An alteration in the expression of vinculin was also observed in other cell systems. Vinculin was detected in both normal 3Y1 and in relatively weakly malignant transformed 3Y1 cell lines, while vinculin was either scarcely detected or not detected at all in more malignant cell lines. These results suggest that the suppression of vinculin is closely related to malignant progression in both the B16-melanoma and 3Y1 cell systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.