Evidence map›Paper›PMID 16446478›Full record

ReviewCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2006

Epigenetics and human disease: translating basic biology into clinical applications.

David Rodenhiser, Mellissa Mann

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00755677 (Exploring the Health Benefits Associated With Daily Pulse Consumption in Individuals With Peripheral Arterial Disease), which is not on this map. Cited by 129 papers.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00755677 early_phase1completednot on this mapstarted 2007, after this paper: background citation

Exploring the Health Benefits Associated With Daily Pulse Consumption in Individuals With Peripheral Arterial Disease

TypeinterventionalSponsorSt. Boniface HospitalRan2007 to 2008Enrolled26ConditionsPeripheral Arterial DiseaseArmsPulses
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 471 citations in OpenAlex.

  1. A Bioinformatics and Wet-Lab-Based Pipeline IdentifiesInternational journal of molecular sciences · 2026
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  12. Epigenetic Analysis of the Dopamine Transporter GeneInternational journal of molecular sciences · 2023
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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David RodenhiserEpiGenWestern Research Group, Children's Health Research Institute, London, Ont. drodenhi@uwo.ca
Mellissa Mann
Children’s Health Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetics refers to the study of heritable changes in gene expression that occur without a change in DNA sequence. Research has shown that epigenetic mechanisms provide an "extra" layer of transcriptional control that regulates how genes are expressed. These mechanisms are critical components in the normal development and growth of cells. Epigenetic abnormalities have been found to be causative factors in cancer, genetic disorders and pediatric syndromes as well as contributing factors in autoimmune diseases and aging. In this review, we examine the basic principles of epigenetic mechanisms and their contribution to human health as well as the clinical consequences of epigenetic errors. In addition, we address the use of epigenetic pathways in new approaches to diagnosis and targeted treatments across the clinical spectrum.

Indexed as

Epigenesis, GeneticGenetic Diseases, InbornGenetic Predisposition to DiseaseAgingDiagnosis, DifferentialDNA MethylationHistonesHumansNeoplasmsReproductive Techniques, AssistedHistones

Identifiers

PMID16446478
PMCPMC1373719
OpenAlexW2063050419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.