ArticleProceedings of the National Academy of Sciences of the United States of America2006
Odorant responses of olfactory sensory neurons expressing the odorant receptor MOR23: a patch clamp analysis in gene-targeted mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed.
- Intrinsic Diversity in Odor-Evoked Calcium Rises acrossThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Simultaneous recording of spikes and calcium signals in odor-evoked responses ofJournal of neurogenetics · 2025Article
- Convergent motifs of early olfactory processing are recapitulated by layer-wise efficient coding.bioRxiv : the preprint server for biology · 2025Article
- Article
- Odors as cognitive constructs: history of odor classification and attempts to map odor percepts to physical and chemical parameters.Chemical senses · 2025Review
- Perceptual constancy for an odor is acquired through changes in primary sensory neurons.Science advances · 2024Article
- Development of an rpS6-Based Ex Vivo Assay for the Analysis of Neuronal Activity in Mouse and Human Olfactory Systems.International journal of molecular sciences · 2024Article
- Olfactory cilia, regulation and control of olfaction.Physiological reports · 2024Review
- Geosmin, a Food- and Water-Deteriorating Sesquiterpenoid and Ambivalent Semiochemical, Activates Evolutionary Conserved Receptor OR11A1.Journal of agricultural and food chemistry · 2024Article
- Role of Ectopic Olfactory Receptors in the Regulation of the Cardiovascular-Kidney-Metabolic Axis.Life (Basel, Switzerland) · 2024Review
- Deciphering the population structure and genetic basis of growth traits from whole-genome resequencing of the leopard coral grouper (Zoological research · 2024Article
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- A 3D transcriptomics atlas of the mouse nose sheds light on the anatomical logic of smell.Cell reports · 2022Article
- Resolving different presynaptic activity patterns within single olfactory glomeruli of Xenopus laevis larvae.Scientific reports · 2021Article
- Stimulus Driven Functional Transformations in the Early Olfactory System.Frontiers in cellular neuroscience · 2021Article
- The cyclic AMP signaling pathway in the rodent main olfactory system.Cell and tissue research · 2021Review
- Antagonistic odor interactions in olfactory sensory neurons are widespread in freely breathing mice.Nature communications · 2020Article
- Interhemispheric asymmetry of c-Fos expression in glomeruli and the olfactory tubercle following repeated odor stimulation.FEBS open bio · 2020Article
- Sensory coding mechanisms revealed by optical tagging of physiologically defined neuronal types.Science (New York, N.Y.) · 2019Article
26 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
A glomerulus in the mammalian olfactory bulb receives axonal inputs from olfactory sensory neurons (OSNs) that express the same odorant receptor (OR). Glomeruli are generally thought to represent functional units of olfactory coding, but there are no data on the electrophysiological properties of OSNs that express the same endogenous OR. Here, using patch clamp recordings in an intact epithelial preparation, we directly measured the transduction currents and receptor potentials from the dendritic knobs of mouse OSNs that express the odorant receptor MOR23 along with the green fluorescent protein. All of the 53 cells examined responded to lyral, a known ligand for MOR23. There were profound differences in response kinetics, particularly in the deactivation phase. The cells were very sensitive to lyral, with some cells responding to as little as 10 nM. The dynamic range was unexpectedly broad, with threshold and saturation in individual cells often covering three log units of lyral concentration. The potential causes and biological significance of this cellular heterogeneity are discussed. Patch clamp recording from OSNs that express a defined OR provides a powerful approach to investigate the sensory inputs to individual glomeruli.
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