ArticleProceedings of the National Academy of Sciences of the United States of America2006
A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 109 citations in OpenAlex.
- A molecular systems perspective on calcium oscillations beyond ion fluxes.Current opinion in cell biology · 2025Review
- Role of cytosolic and endoplasmic reticulum CaPflugers Archiv : European journal of physiology · 2024Review
- Calcium oscillations in HEK293 cells lacking SOCE suggest the existence of a balanced regulation of IPFrontiers in systems biology · 2024Article
- The signal that stimulates mammalian embryo development.Frontiers in cell and developmental biology · 2024Review
- Sperm-Induced CaCells · 2023Review
- Modeling IPBiophysical journal · 2023Article
- Computational investigation of IPScientific reports · 2023Article
- Calcium Dynamics and Water Transport in Salivary Acinar Cells.Bulletin of mathematical biology · 2021Review
- IPiScience · 2020Article
- A Model ofBulletin of mathematical biology · 2019Article
- Estradiol-Mediated Axogenesis of Hypothalamic Neurons Requires ERK1/2 and Ryanodine Receptors-Dependent Intracellular CaFrontiers in cellular neuroscience · 2019Article
- PLCζ Induced CaFrontiers in cell and developmental biology · 2018Article
- Mathematical investigation of IPJournal of computational neuroscience · 2017Article
- The relative contributions of store-operated and voltage-gated CaThe Journal of physiology · 2017Article
- Modeling calcium waves in an anatomically accurate three-dimensional parotid acinar cell.Journal of theoretical biology · 2017Article
- On the dynamical structure of calcium oscillations.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Critical role of ATP-induced ATP release for Ca2+ signaling in nonsensory cell networks of the developing cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Regularization Techniques to Overcome Overparameterization of Complex Biochemical Reaction Networks.IEEE life sciences letters · 2016Article
- Cellular Interrogation: Exploiting Cell-to-Cell Variability to Discriminate Regulatory Mechanisms in Oscillatory Signalling.PLoS computational biology · 2016Article
- The Phase Lag between Agonist-Induced Oscillatory CaCalcium signaling (Santa Clara, Calif.) · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
In some cell types, oscillations in the concentration of free intracellular calcium ([Ca2+]) are accompanied by oscillations in the concentration of inositol 1,4,5-trisphosphate ([IP3]). However, in most cell types it is still an open question as to whether oscillations in [IP3] are necessary for Ca2+ oscillations in vivo, or whether they merely follow passively. Using a wide range of models, we show that the response to an artificially applied pulse of IP3 can be used to distinguish between these two cases. Hence, we show that muscarinic receptor-mediated, long-period Ca2+ oscillations in pancreatic acinar cells depend on [IP3] oscillations, whereas short-period Ca2+ oscillations in airway smooth muscle do not.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.