ArticleProceedings of the National Academy of Sciences of the United States of America2006
Imaging hair cell transduction at the speed of sound: dynamic behavior of mammalian stereocilia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- The tympanic covering layer contributes to basilar membrane elasticity potentially influencing human frequency resolution and speech perception.Journal of anatomy · 2026Article
- The tectorial membrane has a critical role in metabolic age-related hearing loss.EBioMedicine · 2025Article
- The sensitivity of mechanoelectrical transduction response phase to acoustic overstimulation is calcium-dependent.Pflugers Archiv : European journal of physiology · 2024Article
- The Relevance of Autophagy within Inner Ear in Baseline Conditions and Tinnitus-Related Syndromes.International journal of molecular sciences · 2023Review
- Best frequencies and temporal delays are similar across the low-frequency regions of the guinea pig cochlea.Science advances · 2022Article
- Extensive hearing loss induced by low-frequency noise exposure.Laryngoscope investigative otolaryngology · 2022Article
- Elucidation of a lingual detection mechanism for high-viscosity solutions in humans.Food & function · 2022Article
- A flexible anatomical set of mechanical models for the organ of Corti.Royal Society open science · 2021Article
- In situ motions of individual inner-hair-cell stereocilia from stapes stimulation in adult mice.Communications biology · 2021Article
- Inner hair cell stereocilia are embedded in the tectorial membrane.Nature communications · 2021Article
- Cochlear mechanics: new insights from vibrometry and Optical Coherence Tomography.Current opinion in physiology · 2020Article
- An analytic approach to identifying the sources of the low-frequency round window cochlear response.Hearing research · 2019Article
- Control of hearing sensitivity by tectorial membrane calcium.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Olivocochlear efferents: Their action, effects, measurement and uses, and the impact of the new conception of cochlear mechanical responses.Hearing research · 2018Review
- The Competition between the Noise and Shear Motion Sensitivity of Cochlear Inner Hair Cell Stereocilia.Biophysical journal · 2018Article
- Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.Comprehensive Physiology · 2017Review
- Simulating the Chan-Hudspeth experiment on an active excised cochlear segment.The Journal of the Acoustical Society of America · 2017Article
- Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Minimal basilar membrane motion in low-frequency hearing.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Effects of salicylate on sound-evoked outer hair cell stereocilia deflections.Pflugers Archiv : European journal of physiology · 2015Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The cochlea contains two types of sensory cells, the inner and outer hair cells. Sound-evoked deflection of outer hair cell stereocilia leads to fast force production that will enhance auditory sensitivity up to 1,000-fold. In contrast, inner hair cells are thought to have a purely receptive function. Deflection of their stereocilia produces receptor potentials, transmitter release, and action potentials in the auditory nerve. Here, we describe a method for rapid confocal imaging. The method was used to image stereocilia during simultaneous sound stimulation in an in vitro preparation of the guinea pig cochlea. We show that inner hair cell stereocilia move because they interact with the fluid surrounding the hair bundles, but stereocilia deflection occurs at a different phase of the stimulus than is generally expected. In outer hair cells, stereocilia deflections were approximately 1/3 of the reticular lamina displacement. Smaller deflections were found in inner hair cells. The ratio between stereocilia deflection and reticular lamina displacement is important for auditory function, because it determines the stimulus applied to transduction channels. The low ratio measured here suggests that amplification of hair-bundle movements may be necessary in vivo to preserve transduction fidelity at low stimulus levels. In the case of the inner hair cells, this finding would represent a departure from traditional views on their function.
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