ArticleThe Journal of experimental medicine2006
B cell-deficient NOD.H-2h4 mice have CD4+CD25+ T regulatory cells that inhibit the development of spontaneous autoimmune thyroiditis.
Article in The Journal of experimental medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 73 citations in OpenAlex.
- Peripheral immunophenotyping of AITD subjects reveals alterations in immune cells in pediatric vs adult-onset AITD.iScience · 2022Article
- Disappearance of Anti-Thyroid Autoantibodies following Thymectomy in Patients with Myasthenia Gravis.European thyroid journal · 2021Article
- Reversal of Abnormal CD4+ T Cell Metabolism Alleviates Thyroiditis by Deactivating the mTOR/HIF1a/Glycolysis Pathway.Frontiers in endocrinology · 2021Article
- Activation of thyroid antigen-reactive B cells in recent onset autoimmune thyroid disease patients.Journal of autoimmunity · 2018Article
- CD19Experimental and therapeutic medicine · 2017Article
- The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells.The Journal of biological chemistry · 2017Article
- Mechanisms by Which B Cells and Regulatory T Cells Influence Development of Murine Organ-Specific Autoimmune Diseases.Journal of clinical medicine · 2017Review
- The possible role of CD4⁺CD25(high)Foxp3⁺/CD4⁺IL-17A⁺ cell imbalance in the autoimmunity of patients with Hashimoto thyroiditis.Endocrine · 2015Article
- Does microbiota composition affect thyroid homeostasis?Endocrine · 2015Review
- What Causes Biliary Atresia? Unique Aspects of the Neonatal Immune System Provide Clues to Disease Pathogenesis.Cellular and molecular gastroenterology and hepatology · 2015Article
- Regulatory T cells in B-cell-deficient and wild-type mice differ functionally and in expression of cell surface markers.Immunology · 2015Article
- Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity.Endocrine reviews · 2014Review
- Follicular B cells in thyroids of mice with spontaneous autoimmune thyroiditis contribute to disease pathogenesis and are targets of anti-CD20 antibody therapy.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Reduced effectiveness of CD4+Foxp3+ regulatory T cells in CD28-deficient NOD.H-2h4 mice leads to increased severity of spontaneous autoimmune thyroiditis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Transient depletion of CD4+ CD25+ regulatory T cells results in multiple autoimmune diseases in wild-type and B-cell-deficient NOD mice.Immunology · 2013Article
- B cell deficient mice are protected from biliary obstruction in the rotavirus-induced mouse model of biliary atresia.PloS one · 2013Article
- Clues to the etiology of bile duct injury in biliary atresia.Seminars in liver disease · 2012Review
- Unraveling effector functions of B cells during infection: the hidden world beyond antibody production.Infectious disorders drug targets · 2012Review
- Transient depletion of B cells in young mice results in activation of regulatory T cells that inhibit development of autoimmune disease in adults.International immunology · 2012Article
- B cell depletion enhances T regulatory cell activity essential in the suppression of arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Wild-type (WT) NOD.H-2h4 mice develop spontaneous autoimmune thyroiditis (SAT) when given 0.05% NaI in their drinking water, whereas B cell-deficient NOD.H-2h4 mice are SAT resistant. To test the hypothesis that resistance of B cell-deficient mice to SAT was due to the activity of regulatory CD4+CD25+ T (T reg) cells activated if autoantigen was initially presented on non-B cells, CD25+ T reg cells were transiently depleted in vivo using anti-CD25. B cell-deficient NOD.H-2h4 mice given three weekly injections of anti-CD25 developed SAT 8 wk after NaI water. Thyroid lesions were similar to those in WT mice except there were no B cells in thyroid infiltrates. WT and B cell-deficient mice had similar numbers of CD4+CD25+Foxp3+ cells. Mice with transgenic nitrophenyl-specific B cells unable to secrete immunoglobulin were also resistant to SAT, and transient depletion of T reg cells resulted in severe SAT with both T and B cells in thyroid infiltrates. T reg cells that inhibit SAT were eliminated by day 3 thymectomy, indicating they belong to the subset of naturally occurring T reg cells. However, T reg cell depletion did not increase SAT severity in WT mice, suggesting that T reg cells may be nonfunctional when effector T cells are activated; i.e., by autoantigen-presenting B cells.
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