ArticleThe Biochemical journal2006
Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene.
Article in The Biochemical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 72 citations in OpenAlex.
- Article
- Upregulation of SLC38A2 by melatonin attenuates hippocampal ferroptosis in Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Article
- Impaired skeletal muscle hypertrophy signaling and amino acid deprivation response in Apoe knockout mice with an unhealthy lipoprotein distribution.Scientific reports · 2021Article
- Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor.Cancer science · 2021Article
- Interplay of Carbonic Anhydrase IX With Amino Acid and Acid/Base Transporters in the Hypoxic Tumor Microenvironment.Frontiers in cell and developmental biology · 2020Review
- CDK7 is a component of the integrated stress response regulating SNAT2 (SLC38A2)/System A adaptation in response to cellular amino acid deprivation.Biochimica et biophysica acta. Molecular cell research · 2019Article
- Effects of Sodium and Amino Acid Substrate Availability upon the Expression and Stability of the SNAT2 (SLC38A2) Amino Acid Transporter.Frontiers in pharmacology · 2018Article
- Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets.Frontiers in pharmacology · 2018Article
- Nutritional Stress Induced by Amino Acid Starvation Results in Changes for Slc38 Transporters in Immortalized Hypothalamic Neuronal Cells and Primary Cortex Cells.Frontiers in molecular biosciences · 2018Article
- Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters.Scientific reports · 2017Article
- The gene expression of numerous SLC transporters is altered in the immortalized hypothalamic cell line N25/2 following amino acid starvation.FEBS open bio · 2017Article
- The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake.Journal of molecular neuroscience : MN · 2017Article
- Nutrient Sensing: Another Chemosensitivity of the Olfactory System.Frontiers in physiology · 2017Review
- The gene expression of the neuronal protein, SLC38A9, changes in mouse brain after in vivo starvation and high-fat diet.PloS one · 2017Article
- The Neuronal and Peripheral Expressed Membrane-Bound UNC93A Respond to Nutrient Availability in Mice.Frontiers in molecular neuroscience · 2017Article
- Influence of Amino Acid Metabolism on Embryonic Stem Cell Function and Differentiation.Advances in nutrition (Bethesda, Md.) · 2016Review
- Article
- Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability.The Journal of biological chemistry · 2015Article
- Differential adaptive responses to 1- or 2-day fasting in various mouse tissues revealed by quantitative PCR analysis.FEBS open bio · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The neutral amino acid transport activity, System A, is enhanced by amino acid limitation of mammalian cells. Of the three gene products that encode System A activity, the one that exhibits this regulation is SNAT2 (sodium-coupled neutral amino acid transporter 2). Fibroblasts that are deficient in the amino acid response pathway exhibited little or no induction of SNAT2 mRNA. Synthesis of SNAT2 mRNA increased within 1-2 h after amino acid removal from HepG2 human hepatoma cells. The amino acid responsive SNAT2 genomic element that mediates the regulation has been localized to the first intron. Increased binding of selected members of the ATF (activating transcription factor) and C/EBP (CCAAT/enhancer-binding protein) families to the intronic enhancer was established both in vitro and in vivo. In contrast, there was no significant association of these factors with the SNAT2 promoter. Expression of exogenous individual ATF and C/EBP proteins documented that specific family members are associated with either activation or repression of SNAT2 transcription. Chromatin immunoprecipitation analysis established in vivo that amino acid deprivation led to increased RNA polymerase II recruitment to the SNAT2 promoter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.