ArticleThorax2006
Inhaled corticosteroids and decline of lung function in community residents with asthma.
Article in Thorax, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03207620 (Interrelation Between Bronchial Asthma and Smoking), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interrelation Between Bronchial Asthma and Smoking
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Does the use of inhaled corticosteroids in asthma benefit lung function in the long-term? A systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2021Pooled it
- Asthma worsenings: approaches to prevention and management from the Asthma Worsenings Working Group.Canadian respiratory journalGuideline
- Rhinovirus-16 induced temporal interferon responses in nasal epithelium links with viral clearance and symptoms.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Longitudinal changes in airway remodeling and air trapping in severe asthma.Academic radiology · 2014Trial
- Smoking and Lung Function Response to Inhaled Glucocorticoids in Adult-Onset Asthma.Journal of asthma and allergy · 2026Article
- Global airways: a Danish nationwide real-life registry of biologic therapy for chronic rhinosinusitis with nasal polyps.Frontiers in allergy · 2025Article
- Association of demographic variables and smoking habits with the severity of lung function in adult smokers.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Article
- Lung Function Decline in Adult Asthmatics-A 10-Year Follow-Up Retrospective and Prospective Study.Diagnostics (Basel, Switzerland) · 2021Article
- Lessons learned from targeting eosinophils in human disease.Seminars in immunopathology · 2021Review
- Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate-to-Severe Asthma.American journal of respiratory and critical care medicine · 2021Article
- MicroRNAs as Biomarkers in Corticosteroid-Resistant/Neutrophilic Asthma: Still a Long Way to Go!American journal of respiratory and critical care medicine · 2020Article
- FEVThe World Allergy Organization journal · 2020Article
- Asthma progression and mortality: the role of inhaled corticosteroids.The European respiratory journal · 2019Review
- Determinants of airflow limitation in Danish adults - findings from the Health2006 cohort.International journal of chronic obstructive pulmonary disease · 2019Article
- Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma.Scientific reports · 2017Article
- Longitudinal trends in clinical characteristics and lung function of patients with severe asthma under treatment in Brazil.BMC pulmonary medicine · 2016Article
- Inhaler technique: facts and fantasies. A view from the Aerosol Drug Management Improvement Team (ADMIT).NPJ primary care respiratory medicine · 2016Review
- The Danish National Database for Asthma: establishing clinical quality indicators.European clinical respiratory journal · 2016Review
- Revisiting early intervention in adult asthma.ERJ open research · 2015Review
- The relation of airway obstruction to asthma, chronic rhinosinusitis and age: results from a population survey of adults.Allergy · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInhaled corticosteroids (ICS) constitute the cornerstone of treatment for asthma. Many studies have reported beneficial short term effects of these drugs, but there are few data on the long term effects of ICS on the decline in forced expiratory volume in 1 second (FEV(1)). This study was undertaken to determine whether adults with asthma treated with ICS have a less pronounced decline in FEV(1) than those not treated with ICS.
methodsTwo hundred and thirty four asthmatic individuals from a longitudinal epidemiological study of the general population of Copenhagen, Denmark were divided into two groups; 44 were treated with ICS and 190 were not treated with ICS. The annual decline in FEV(1) was measured over a 10 year follow up period.
resultsThe decline in FEV(1) in the 44 patients receiving ICS was 25 ml/year compared with 51 ml/year in the 190 patients not receiving this treatment (p<0.001). The linear regression model with ICS as the variable of interest and sex, smoking, and wheezing as covariates showed that treatment with ICS was associated with a less steep decline in FEV(1) of 18 ml/year (p = 0.01). Adjustment for additional variables including age, socioeconomic status, body mass index, mucus hypersecretion, and use of other asthma medications did not change these results.
conclusionsTreatment with ICS is associated with a significantly reduced decline in ventilatory function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.