ArticleArchives of disease in childhood2006
A prospective questionnaire assessment of attitudes and experiences of off label prescribing among hospital based paediatricians.
Article in Archives of disease in childhood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Parental awareness, attitudes and decision-making of off-label use in children: a systematic review and meta-analysis.BMJ paediatrics open · 2026Pooled it
- Factors affecting uptake and adherence to breast cancer chemoprevention: a systematic review and meta-analysis.Annals of oncology : official journal of the European Society for Medical Oncology · 2016Pooled it
- Awareness, knowledge and views of off-label prescribing in children: a systematic review.British journal of clinical pharmacology · 2015Pooled it
- Off-Label Pediatric Medication Prescribing and Dispensing: Awareness and Attitudes among Community Pharmacists: A Questionnaire-Based Study.Pharmacy (Basel, Switzerland) · 2024Article
- Off-label prescription: developing a guideline and validating an instrument to measure physicians' and clinical pharmacists' knowledge and attitudes toward off-label medication use.Journal of diabetes and metabolic disorders · 2023Article
- Off-label use of medicines in neonates, infants, children, and adolescents: a joint policy statement by the European Academy of Paediatrics and the European society for Developmental Perinatal and Pediatric Pharmacology.European journal of pediatrics · 2020Article
- Off-label Medications Use in the Eastern Province of Saudi Arabia: The Views of General Practitioners, Pediatricians, and Other Specialists.Hospital pharmacy · 2020Article
- Exploratory Findings of Prescribing Unlicensed and Off-Label Medicines Among Children and Neonates.Integrated pharmacy research & practice · 2020Article
- Current practice and awareness of pediatric off-label drug use in Shanghai, China -a questionnaire-based study.BMC pediatrics · 2019Article
- Attitudes, knowledge and views on off-label prescribing in children among healthcare professionals in Malaysia.International journal of clinical pharmacy · 2019Article
- Delays in completion and results reporting of clinical trials under the Paediatric Regulation in the European Union: A cohort study.PLoS medicine · 2018Article
- Perceptions and attitudes towards off-label dispensing for pediatric patients, a study of hospital based pharmacists in Jordan.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
- Off-Label Prescribing for Children with Migraines in U.S. Ambulatory Care Settings.Journal of managed care & specialty pharmacy · 2017Article
- Maltese prescribers use of off-label and unlicensed medicines in children: perceptions and attitudes.International journal of clinical pharmacy · 2016Article
- Perceptions and attitudes of Jordanian paediatricians towards off-label paediatric prescribing.International journal of clinical pharmacy · 2011Article
- Article
- Healthcare professional experiences and attitudes on unlicensed/off-label paediatric prescribing and paediatric clinical trials.European journal of clinical pharmacology · 2011Article
- Drug formulations that require less than 0.1 mL of stock solution to prepare doses for infants and children.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2011Article
- Access to children's medicines in the United Kingdom, Australia and New Zealand in 1998, 2002 and 2007.Pharmacy world & science : PWS · 2010Article
- A pilot study to evaluate a community pharmacy-based monitoring system to identify adverse drug reactions associated with paediatric medicines use.European journal of clinical pharmacology · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess current attitudes of hospital based paediatricians to off label prescribing, and the performance of clinical trials in children.
designA prospective, questionnaire based study.
setting257 hospital based consultants and specialist registrars in paediatric practice in Scotland during 2003-2004.
resultsA 25 item questionnaire was sent to 257 hospital based paediatricians and 151 (59%) were returned completed. Over 90% of responders were familiar with the concept of, and knowingly prescribed, off label drugs; 55% of responders stated that such prescribing disadvantaged children, and 47% expressed concerns about the efficacy of off label medicines. Although 70% of responders expressed concerns about safety, only 17% had observed an adverse event, and 47% a treatment failure, while 69% did not obtain informed consent or tell parents they were prescribing off label, and 67% did not inform the family's general practitioner. Many respondents did not believe it was necessary to carry out clinical trials in children for new (46%) or generic (64%) medicines. However, 52% of respondents stated that they would be willing to undertake clinical studies and recruit their own patients (61%) or children (73%) to take part in such studies.
conclusionsAmong Scottish paediatricians there is concern about off label prescribing, although the majority do not consider it necessary to inform parents or GP colleagues. The need for clinical trials in children was recognised but there was a less than wholehearted acceptance of the need for such studies, at variance with the current drive to promote clinical trials in this age group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.