ArticleJournal of the American Society for Mass Spectrometry2006
Characterization of specific noncovalent complexes between guanidinium derivatives and single-stranded DNA by MALDI.
Article in Journal of the American Society for Mass Spectrometry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- MALDI Matrix: Origins, Innovations, and Frontiers.Chemical reviews · 2026Review
- Highly sensitive pork meat detection using copper(ii) tetraaza complex by electrochemical biosensor.RSC advances · 2023Article
- Interactions of Protonated Guanidine and Guanidine Derivatives with Multiply Deprotonated RNA Probed by Electrospray Ionization and Collisionally Activated Dissociation.ChemistryOpen · 2017Article
- Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs.Nucleic acids research · 2015Article
- In vitro interactions between 17β-estradiol and DNA result in formation of the hormone-DNA complexes.International journal of environmental research and public health · 2014Article
- Excursions in polynuclear platinum DNA binding.Chemical communications (Cambridge, England) · 2010Article
- Matrix-assisted laser desorption/ionization mass spectrometric analysis of polysulfated-derived oligosaccharides using pyrenemethylguanidine.Journal of the American Society for Mass Spectrometry · 2009Article
- Noncovalent complexes between DNA and basic polypeptides or polyamines by MALDI-TOF.Journal of the American Society for Mass Spectrometry · 2007Article
- A study of noncovalent complexes involving single-stranded DNA and polybasic compounds using nanospray mass spectrometry.Journal of the American Society for Mass Spectrometry · 2007Article
- Current literature in mass spectrometry.Journal of mass spectrometry : JMS · 2007Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noncovalently bound complexes between highly basic sites of 12 guanidinium compounds and single-stranded DNA were studied using matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. 6-Aza-2-thiothymine (ATT) was used as the matrix in the presence of ammonium citrate, and spectra were recorded in the positive ion mode. Detailed control experiments confirmed unambiguously the high selectivity and specificity of the guanidinium moiety for phosphate groups of DNA. The results verify the binding stoichiometry and show preferential binding of hydrophobic binders (pyrene and anthracene guanidinium derivatives) to all sequences examined. In addition, we demonstrate that electrostatic noncovalent interactions are strengthened with phosphorothioate analogs of DNA. These results clearly highlight the structure-directing role of the self-assembling organic species and strongly emphasize the significance of concentration, hydrophobicity, hydrogen-bonding, and pi-pi interactions of the artificial receptor in the formation of these noncovalent complexes. Because of the ability of DNA-binding compounds to influence gene expression, and therefore cell proliferation and differentiation, the interactions described above could be important in providing a better understanding of the mechanism of action of these noncovalent genetic regulators.
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