ArticleGut1992
Cytokine production in patients with inflammatory bowel disease.
Article in Gut, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00727324 (A Pilot, Open-label, Multi-center Clinical Trial to Investigate the Safety and Efficacy of Bovine-Calf Intestinal Alkaline Phosphatase in Patients With Moderate to Severe Ulcerative Colitis.), which is not on this map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot, Open-label, Multi-center Clinical Trial to Investigate the Safety and Efficacy of Bovine-Calf Intestinal Alkaline Phosphatase in Patients With Moderate to Severe Ulcerative Colitis.
Who cites it
44 citing papers in PubMed, 118 citations in OpenAlex.
- Interferon beta-1a in ulcerative colitis: a placebo controlled, randomised, dose escalating study.Gut · 2003Trial
- Anti-inflammatory effects and gut microbiota modulation of synbiotic mulberry in DSS-induced colitis rats.Molecular and cellular biochemistry · 2025Article
- Topological Reorganization and Resting-State Functional Connectivity in Functional Dyspepsia: Associations of Symptoms with Peripheral Cytokine Levels and Amygdala Nodal Centrality.Molecular neurobiology · 2025Article
- Improvement Effect and Mechanism of Hydroxytyrosol on Skin Aging Induced Advanced Glycation End Products.Nutrients · 2025Article
- IL1B Increases Intestinal Tight Junction Permeability by Up-regulation of MIR200C-3p, Which Degrades Occludin mRNA.Gastroenterology · 2020Article
- Inhibition of LSD1 phosphorylation alleviates colitis symptoms induced by dextran sulfate sodium.BMB reports · 2020Article
- Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection.International journal of molecular sciences · 2019Review
- The Inflammatory Response to EnterotoxigenicMediators of inflammation · 2018Article
- Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins.Molecular biology of the cell · 2014Article
- Plasma cytokine profiling in sibling pairs discordant for autism spectrum disorder.Journal of neuroinflammation · 2013Article
- Intestinal anti-inflammatory activity of lentinan: influence on IL-8 and TNFR1 expression in intestinal epithelial cells.PloS one · 2013Article
- IFN-γ and TNF-α-induced GBP-1 inhibits epithelial cell proliferation through suppression of β-catenin/TCF signaling.Mucosal immunology · 2012Article
- The Role of Th17 in Neuroimmune Disorders: Target for CAM Therapy. Part II.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- IL-1beta-induced increase in intestinal epithelial tight junction permeability is mediated by MEKK-1 activation of canonical NF-kappaB pathway.The American journal of pathology · 2010Article
- Lactobacillus plantarum prevents the upregulation of adhesion molecule expression in an experimental colitis model.Digestive diseases and sciences · 2010Article
- Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways.Immunity · 2010Article
- Cytokine regulation of tight junctions.Biochimica et biophysica acta · 2009Review
- Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Alterations in the function of circulating mononuclear cells derived from patients with Crohn's disease treated with mastic.World journal of gastroenterology · 2007Article
- IL-1beta causes an increase in intestinal epithelial tight junction permeability.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The production of cytokines in peripheral blood mononuclear leukocytes of patients with inflammatory bowel disease was investigated. T cell subset analysis and differential white blood cell counts were also performed. Thirty five patients with ulcerative colitis, 14 with Crohn's disease, and 15 age matched healthy volunteers were studied. No differences were observed in T cell subsets and OKT4/OKT8 ratios in patients with ulcerative colitis or Crohn's disease compared with controls. Interleukin 1 beta production was significantly increased in active ulcerative colitis and Crohn's disease, compared with values in controls, but returned to control levels in the inactive stages. In addition, in active ulcerative colitis and Crohn's disease, there were significant correlations between the interleukin 1 beta production and the ulcerative colitis activity index or Crohn's disease activity index. Interleukin 2 production was also significantly increased in the active ulcerative colitis and significantly correlated to the activity index, but there was no change in Crohn's disease patients compared with controls. Gamma interferon production in patients was the same as that in controls. This study suggests that the interleukin 1 beta and 2 values in peripheral mononuclear leukocytes of active untreated inflammatory bowel disease are indicators of the disease states of ulcerative colitis or Crohn's disease, or both.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.