ArticleJournal of anatomy2006
Perinatal development of the pancreatic islet microvasculature in rats.
Article in Journal of anatomy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Preservation of pancreatic endocrine and peri-islet exocrine capillary networks in type 2 diabetes.JCI insight · 2026Article
- Defining the islet: a minimum size threshold and opportunities for standardization.Frontiers in endocrinology · 2026Review
- The role of endothelial cells in pancreatic islet development, transplantation and culture.Frontiers in cell and developmental biology · 2025Review
- Article
- Neonatal Diabetes in Patients Affected by Liang-Wang Syndrome Carrying KCNMA1 Variant p.(Gly375Arg) Suggest a Potential Role of CaCurrent issues in molecular biology · 2021Article
- A Chronic Fetal Leucine Infusion Potentiates Fetal Insulin Secretion and Increases Pancreatic Islet Size, Vascularity, and β Cells in Late-Gestation Sheep.The Journal of nutrition · 2020Article
- Adipose tissue-derived mesenchymal stem cells rescue the function of islets transplanted in sub-therapeutic numbers via their angiogenic properties.Cell and tissue research · 2019Article
- Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature.eLife · 2018Article
- Article
- Signals in the pancreatic islet microenvironment influence β-cell proliferation.Diabetes, obesity & metabolism · 2017Review
- Intra-islet endothelial cell and β-cell crosstalk: Implication for islet cell transplantation.World journal of transplantation · 2017Review
- Effective endothelial cell and human pluripotent stem cell interactions generate functional insulin-producing beta cells.Diabetologia · 2016Article
- Pancreatic islet blood flow and its measurement.Upsala journal of medical sciences · 2016Review
- Endothelium-derived essential signals involved in pancreas organogenesis.World journal of experimental medicine · 2015Review
- Article
- Preculturing Islets With Adipose-Derived Mesenchymal Stromal Cells Is an Effective Strategy for Improving Transplantation Efficiency at the Clinically Preferred Intraportal Site.Cell medicine · 2014Article
- Article
- Ontogeny of neuro-insular complexes and islets innervation in the human pancreas.Frontiers in endocrinology · 2014Article
- Omentum is better site than kidney capsule for growth, differentiation, and vascularization of immature porcine β-cell implants in immunodeficient rats.Transplantation · 2013Article
- Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation.Developmental biology · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to investigate possible changes in the islet microvasculature during the period of pronounced beta-cell growth seen perinatally in rats. We studied islet endothelial and beta-cell proliferation, as well as islet vascular density, in rats during this period. There was a progressive increase in islet vascular density from day -1 to day 7 postpartum, with values similar to those in adult rats seen at the latter time point. (3)H-thymidine-labelled islet endothelial cells were extremely rare in adult rats, whereas such cells were much more frequent perinatally. The beta-cell labelling index was higher in all perinatal animals than in adult rats, with peak values seen on day 2. The proliferating endocrine cells were located very close to blood vessels at day 2 after birth. In conclusion, the pronounced growth of islet endocrine cells seen during the first week after birth coincides and co-localizes with an even more pronounced increase in islet endothelial cell proliferation, which results in a marked increase in intra-islet vascular density. This perinatal increase in islet blood vessel density may facilitate glucose sensing and islet hormonal delivery to the systemic circulation.
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