ArticleJournal of anatomy2006
An in situ hybridization study of Runx2, Osterix, and Sox9 at the onset of condylar cartilage formation in fetal mouse mandible.
Article in Journal of anatomy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Global distribution of malocclusion traits: A systematic review.Dental press journal of orthodonticsPooled it
- Meckel's cartilage midsegment: spatiotemporal dynamics and osteogenic role in mice.Cell and tissue research · 2026Article
- Sclerostin modulates mineralization degree and stiffness profile in the fibrocartilaginous enthesis for mechanical tissue integrity.Frontiers in cell and developmental biology · 2024Article
- A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2.Journal of dental research · 2024Article
- Identification of distinct subpopulations of Gli1-lineage cells in the mouse mandible.Journal of anatomy · 2023Article
- Identification of a heterogeneous and dynamic ciliome during embryonic development and cell differentiation.Development (Cambridge, England) · 2023Article
- Toward zonally tailored scaffolds for osteochondral differentiation of synovial mesenchymal stem cells.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis.American journal of translational research · 2019Article
- Contrasting patterns of RUNX2 repeat variations are associated with palate shape in phyllostomid bats and New World primates.Scientific reports · 2018Article
- Vital Roles of β-catenin in Trans-differentiation of Chondrocytes to Bone Cells.International journal of biological sciences · 2018Article
- Profiling of Stem/Progenitor Cell Regulatory Genes of the Synovial Joint by Genome-Wide RNA-Seq Analysis.BioMed research international · 2018Article
- Diverse contribution of Col2a1-expressing cells to the craniofacial skeletal cell lineages.Orthodontics & craniofacial research · 2017Article
- Continuous hydrostatic pressure induces differentiation phenomena in chondrocytes mediated by changes in polycystins, SOX9, and RUNX2.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2017Article
- A Joint Less Ordinary: Intriguing Roles for Hedgehog Signalling in the Development of the Temporomandibular Synovial Joint.Journal of developmental biology · 2016Review
- Observing the development of the temporomandibular joint in embryonic and post-natal mice using various staining methods.Experimental and therapeutic medicine · 2016Article
- Mandible and Tongue Development.Current topics in developmental biology · 2015Review
- Critical role of Bmpr1a in mandibular condyle growth.Connective tissue research · 2014Article
- TMJ degeneration in SAMP8 mice is accompanied by deranged Ihh signaling.Journal of dental research · 2014Article
- BMPRIA mediated signaling is essential for temporomandibular joint development in mice.PloS one · 2014Article
- The complex ontogenetic trajectory of mandibular shape in a laboratory mouse.Journal of anatomy · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mandibular condylar cartilage is the principal secondary cartilage, differing from primary cartilage in its rapid differentiation from progenitor cells (preosteoblasts/skeletoblasts) to hypertrophic chondrocytes. The expression of three transcription factors related to bone and cartilage formation, namely Runx2, Osterix and Sox9, was investigated at the onset of mouse mandibular condylar cartilage formation by in situ hybridization. Messenger RNAs for these three molecules were expressed in the condylar anlage, consisting of preosteoblasts/skeletoblasts, at embryonic day (E)14. Hypertrophic chondrocytes appeared at E15 as soon as cartilage tissue appeared. Runx2 mRNA was expressed in the embryonic zone at the posterior position of the newly formed cartilage, in the bone collar and in the newly formed cartilage, but expression intensity in the newly formed cartilage was slightly weaker. Osterix mRNA was also expressed in the embryonic zone and in the bone collar, but was at markedly lower levels in the newly formed cartilage. Sox9 mRNA was continuously expressed from the embryonic zone to the newly formed cartilage. At this stage, Sox5 mRNA was expressed only in the newly formed cartilage. These results suggest that reduced expression of Osterix in combination with Sox9-Sox5 expression is important for the onset of condylar (secondary) cartilage formation.
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