ArticleAlcoholism, clinical and experimental research2006
Actions of acute and chronic ethanol on presynaptic terminals.
Article in Alcoholism, clinical and experimental research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Selectively counteracting cerebellar adaptations to chronic alcohol exposure reduces acute alcohol withdrawal severity in C57BL6/N mice.Neuropharmacology · 2025Article
- Ginger (Zingiber Officinale Roscoe) ameliorates ethanol-induced cognitive impairment by modulating NMDA and GABA-A receptors in rat hippocampus.Metabolic brain disease · 2024Article
- Precocious emergence of cognitive and synaptic dysfunction in 3xTg-AD mice exposed prenatally to ethanol.Alcohol (Fayetteville, N.Y.) · 2023Article
- Drunken lipid membranes, not drunken SNARE proteins, promote fusion in a model of neurotransmitter release.Frontiers in molecular neuroscience · 2022Article
- The Significance of Toll-Like Receptors in the Neuroimmunologic Background of Alcohol Dependence.Frontiers in psychiatry · 2021Review
- Glutamate Transmission to Ventral Tegmental Area GABA Neurons Is Altered by Acute and Chronic Ethanol.Alcoholism, clinical and experimental research · 2018Article
- The Mammalian Circadian Clock Exhibits Chronic Ethanol Tolerance and Withdrawal-Induced Glutamate Hypersensitivity, Accompanied by Changes in Glutamate and TrkB Receptor Proteins.Alcoholism, clinical and experimental research · 2018Article
- Activin Controls Ethanol Potentiation of Inhibitory Synaptic Transmission Through GABAA Receptors and Concomitant Behavioral Sedation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Differential Effects of Toluene and Ethanol on Dopaminergic Neurons of the Ventral Tegmental Area.Frontiers in neuroscience · 2016Article
- Effects of ethanol exposure in utero on Cajal-Retzius cells in the developing cortex.Alcoholism, clinical and experimental research · 2015Article
- Glutamatergic transmission in drug reward: implications for drug addiction.Frontiers in neuroscience · 2015Review
- Presynaptic BK channels modulate ethanol-induced enhancement of GABAergic transmission in the rat central amygdala nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Acute and chronic effects of ethanol on learning-related synaptic plasticity.Alcohol (Fayetteville, N.Y.) · 2014Review
- Alcohol induces synaptotagmin 1 expression in neurons via activation of heat shock factor 1.Neuroscience · 2011Article
- Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in α4 Subunit Knockout Mice.Frontiers in neuroscience · 2011Article
- Ethanol-enhanced GABA release: a focus on G protein-coupled receptors.Brain research reviews · 2011Review
- Cellular and mitochondrial effects of alcohol consumption.International journal of environmental research and public health · 2010Review
- Molecular neurobiology of lead (Pb(2+)): effects on synaptic function.Molecular neurobiology · 2010Review
- The effects of acute and chronic ethanol exposure on presynaptic and postsynaptic gamma-aminobutyric acid (GABA) neurotransmission in cultured cortical and hippocampal neurons.Alcohol (Fayetteville, N.Y.) · 2009Article
- Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats.Alcoholism, clinical and experimental research · 2009Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
This article presents the proceedings of a symposium entitled "The Tipsy Terminal: Presynaptic Effects of Ethanol" (held at the annual meeting of the Research Society on Alcoholism, in Santa Barbara, CA, June 27, 2005). The objective of this symposium was to focus on a cellular site of ethanol action underrepresented in the alcohol literature, but quickly becoming a "hot" topic. The chairs of the session were Marisa Roberto and George Robert Siggins. Our speakers were chosen on the basis of the diverse electrophysiological and other methods used to discern the effects of acute and chronic ethanol on presynaptic terminals and on the basis of significant insights that their data provide for understanding ethanol actions on neurons in general, as mechanisms underlying problematic behavioral effects of alcohol. The 5 presenters drew from their recent studies examining the effects of acute and chronic ethanol using a range of sophisticated methods from electrophysiological analysis of paired-pulse facilitation and spontaneous and miniature synaptic currents (Drs. Weiner, Valenzuela, Zhu, and Morrisett), to direct recording of ion channel activity and peptide release from acutely isolated synaptic terminals (Dr. Treistman), to direct microscopic observation of vesicular release (Dr. Morrisett). They showed that ethanol administration could both increase and decrease the probability of release of different transmitters from synaptic terminals. The effects of ethanol on synaptic terminals could often be correlated with important behavioral or developmental actions of alcohol. These and other novel findings suggest that future analyses of synaptic effects of ethanol should attempt to ascertain, in multiple brain regions, the role of presynaptic terminals, relevant presynaptic receptors and signal transduction linkages, exocytotic mechanisms, and their involvement in alcohol's behavioral actions. Such studies could lead to new treatment strategies for alcohol intoxication, alcohol abuse, and alcoholism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.