Evidence map›Paper›PMID 16440417›Full record

ArticleWorld journal of gastroenterology2006

Clinical significance of subcellular localization of KL-6 mucin in primary colorectal adenocarcinoma and metastatic tissues.

Qian Guo, Wei Tang, Yoshinori Inagaki, Yutaka Midorikawa, Norihiro Kokudo, Yasuhiko Sugawara, Munehiro Nakata, Toshiro Konishi, Hirokazu Nagawa, Masatoshi Makuuchi

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Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
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9citing papers in PubMed, 3 pooled it
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1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Qian GuoHepatobiliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo 113-8655, Japan.
Wei Tang
Yoshinori Inagaki
Yutaka Midorikawa
Norihiro Kokudo
Yasuhiko Sugawara
Munehiro Nakata
Toshiro Konishi
Hirokazu Nagawa
Masatoshi Makuuchi

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo assess subcellular localization of KL-6 mucin and its clinicopathological significance in colorectal carcinoma as well as metastatic lymph node and liver tissues.

methodsColorectal carcinoma tissues as well as metastatic lymph node and liver tissues were collected from 82 patients who underwent colorectomy or hepatectomy. Tissues were subjected to immunohistochemical analysis using KL-6 antibody.

resultsOf the 82 colorectal carcinoma patients, 6 showed no staining, 29 showed positive staining only in the apical membrane, and 47 showed positive staining in the circumferential membrane and/or cytoplasm. Positive staining was not observed in non-cancerous colorectal epithelial cells surrounding the tumor tissues. The five-year survival rate was significantly lower in cases showing positive staining in the circumferential membrane and/or cytoplasm (63.0%) than those showing positive staining only in the apical membrane (85.7%) and those showing no staining (100%). Statistical analysis between clinicopathological factors and subcellular localization of KL-6 mucin showed that KL-6 localization in the circumferential membrane and/or cytoplasm was significantly associated with the presence of venous invasion (P = 0.0003), lymphatic invasion (P<0.0001), lymph node metastasis (P<0.0001), liver metastasis (P = 0.058), and advanced histological stage (P<0.0001). Positive staining was observed in all metastatic lesions tested as well as in the primary colorectal carcinoma tissues.

conclusionThe subcellular staining pattern of KL-6 in colorectal adenocarcinoma may be an important indicator for unfavorable behaviors such as lymph node and liver metastasis, as well as for the prognosis of patients.

Indexed as

AdenocarcinomaAdultAgedAntigensAntigens, NeoplasmColorectal NeoplasmsFemaleGlycoproteinsHumansImmunohistochemistryLymphatic MetastasisMaleMiddle AgedMucin-1MucinsSurvival RateAntigensAntigens, NeoplasmGlycoproteinsMUC1 protein, humanMucin-1Mucins

Identifiers

PMID16440417
PMCPMC4077483

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