ArticleJournal of molecular medicine (Berlin, Germany)2006
The importance of cysteine cathepsin proteases for placental development.
Article in Journal of molecular medicine (Berlin, Germany), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 62 citations in OpenAlex.
- Association of in utero exposure to phthalate and DINCH metabolites with placental DNA methylation.Environment international · 2025Article
- Crosstalk between decidual natural killer cells and extravillous trophoblasts at the maternal-fetal interface: current status and future perspectives.Frontiers in immunology · 2025Review
- Endostatin and Cystatin C as Potential Biomarkers for Early Prediction of Preeclampsia.ACS omega · 2023Article
- Characterization of methylation profiles in spontaneous preterm birth placental villous tissue.PloS one · 2023Article
- Urinary Levels of Cathepsin B in Preterm Newborns.Journal of clinical medicine · 2021Article
- Article
- Functions of Lysosomes in Mammalian Female Reproductive System.Reproductive and developmental medicine · 2020Article
- Discordant placental oxygenation and autophagy in twin anemia-polycythemia sequence (TAPS).Placenta · 2020Article
- Evaluation of serum cathepsin B, D, and L concentrations in women with late-onset preeclampsia.Turkish journal of obstetrics and gynecology · 2019Article
- Pulse of inflammatory proteins in the pregnant uterus of European polecats (Royal Society open science · 2017Article
- CUL4A enhances human trophoblast migration and is associated with pre-eclampsia.International journal of clinical and experimental pathology · 2017Article
- Activity of Proteolytic Enzymes and Level of Cystatin C in the Peripartum Period.BioMed research international · 2016Article
- LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia.The American journal of pathology · 2014Article
- Prediction of preeclampsia-bench to bedside.Current hypertension reports · 2014Review
- A cathepsin B inhibitor, E-64, improves the preimplantation development of bovine somatic cell nuclear transfer embryos.The Journal of reproduction and development · 2014Article
- CUL1 promotes trophoblast cell invasion at the maternal-fetal interface.Cell death & disease · 2013Article
- Extravillous trophoblast and decidual natural killer cells: a remodelling partnership.Human reproduction update · 2012Review
- Uterine gene expression in the live-bearing lizard, Chalcides ocellatus, reveals convergence of squamate reptile and mammalian pregnancy mechanisms.Genome biology and evolution · 2012Article
- Article
- Critical growth factors and signalling pathways controlling human trophoblast invasion.The International journal of developmental biology · 2010Review
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
The typically lysosomal family of cysteine cathepsin proteases has been implicated in the development of the placenta in particular, from studies in the mouse. Here, we analysed overall expression, regulation and presence of transcript isoforms of cysteine cathepsins during human extra-embryonic development. All 11 family members are expressed in human placental tissues, and many are differentially regulated during gestation. Several cysteine cathepsins exhibit deregulated expression levels in placentas from pregnancies complicated by pre-eclampsia. The localization of cathepsin B predominantly in placental and decidual macrophages suggests a role in the physiological functions of these cells in mediating villous angiogenesis and decidual apoptosis. Cathepsin L levels are highest in a subpopulation of invasive cytotrophoblasts. Reflecting the expression pattern of two murine cathepsins, these data give insights into the evolutionary conservation of cathepsin function that is not necessarily exhibited by gene pairs defined by highest sequence similarity. Furthermore, cathepsin L protein localization in uterine epithelial cells demonstrates the in vivo occurrence of intranuclear cathepsin L isoforms. The zonally restricted expression of cathepsin in the syncytiotrophoblast may be important for the metabolic breakdown of maternal nutrients. Overall, the distribution and abnormal expression levels in pre-eclamptic placentas indicate that cysteine cathepsins may play important roles during normal placentation and in the etiology of pre-eclampsia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.