ArticleDevelopment genes and evolution2006
Molecular characterization and embryonic expression of innexins in the leech Hirudo medicinalis.
Article in Development genes and evolution, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Glial Chloride Channels in the Function of the Nervous System Across Species.Advances in experimental medicine and biology · 2021Article
- Gap Junction Channels of Innexins and Connexins: Relations and Computational Perspectives.International journal of molecular sciences · 2019Review
- Gap junction gene and protein families: Connexins, innexins, and pannexins.Biochimica et biophysica acta. Biomembranes · 2018Review
- Innexins: Expression, Regulation, and Functions.Frontiers in physiology · 2018Review
- Article
- Electrical coupling and innexin expression in the stomatogastric ganglion of the crab Cancer borealis.Journal of neurophysiology · 2014Article
- Gap junction-dependent homolog avoidance in the developing CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Arachidonic acid closes innexin/pannexin channels and thereby inhibits microglia cell movement to a nerve injury.Developmental neurobiology · 2013Article
- Ectopic expression of select innexins in individual central neurons couples them to pre-existing neuronal or glial networks that express the same innexin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Molluscan neurons in culture: shedding light on synapse formation and plasticity.Journal of molecular histology · 2012Review
- The medicinal leech genome encodes 21 innexin genes: different combinations are expressed by identified central neurons.Development genes and evolution · 2012Article
- Article
- Gap junction expression is required for normal chemical synapse formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Neuroglial ATP release through innexin channels controls microglial cell movement to a nerve injury.The Journal of general physiology · 2010Article
- Molecular characterization, localization, and distribution of innexins in the silkworm, Bombyx mori.Molecular biotechnology · 2009Article
- CNQX and AMPA inhibit electrical synaptic transmission: a potential interaction between electrical and glutamatergic synapses.Brain research · 2008Article
- What is hidden in the pannexin treasure trove: the sneak peek and the guesswork.Journal of cellular and molecular medicineReview
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Authors and funding
2 authors.
Funding
Abstract
Gap junctions are direct intercellular channels that permit the passage of ions and small signaling molecules. The temporal and spatial regulation of gap junctional communication is, thus, one mechanism by which cell interactions, and hence cell properties and cell fate, may be regulated during development. The nervous system of the leech, Hirudo medicinalis, is a particularly advantageous system in which to study developmental mechanisms involving gap junctions because interactions between identified cells may be studied in vivo in both the embryo and the adult. As in most invertebrates, gap junctions in the leech are composed of innexin proteins, which are distantly related to the vertebrate pannexins and are encoded by a multi-gene family. We have cloned ten novel leech innexins and describe the expression of these, plus two other previously reported members of this gene family, in the leech embryo between embryonic days 6 and 12, a period during which the main features of the central nervous system are established. Four innexins are expressed in neurons and two in glia, while several innexins are expressed in the excretory, circulatory, and reproductive organs. Of particular interest is Hm-inx6, whose expression appears to be restricted to the characterized S cell and two other neurons putatively identified as presynaptic to this cell. Two other innexins also show highly restricted expressions in neurons and may be developmentally regulated.
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