ArticleAmerican journal of respiratory cell and molecular biology2006
Early emphysema in the tight skin and pallid mice: roles of microfibril-associated glycoproteins, collagen, and mechanical forces.
Article in American journal of respiratory cell and molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- The hypoxic tight-skin mouse model of Group 3 pulmonary hypertension.Scientific reports · 2026Article
- A titratable murine model of progressive emphysema using tracheal porcine pancreatic elastase.Scientific reports · 2023Article
- Increased Susceptibility to Glaucomatous Damage in Microfibril Deficient Mice.Investigative ophthalmology & visual science · 2020Article
- Nonlinear elasticity of the lung extracellular microenvironment is regulated by macroscale tissue strain.Acta biomaterialia · 2019Article
- A skeleton-tree-based approach to acinar morphometric analysis using microcomputed tomography with comparison of acini in young and old C57BL/6 mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Critical Appraisal of the Utility and Limitations of Animal Models of Scleroderma.Current rheumatology reports · 2016Review
- Proteoglycans maintain lung stability in an elastase-treated mouse model of emphysema.American journal of respiratory cell and molecular biology · 2014Article
- A network model of correlated growth of tissue stiffening in pulmonary fibrosis.New journal of physics · 2014Article
- Age-related increases in ozone-induced injury and altered pulmonary mechanics in mice with progressive lung inflammation.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo.The Journal of biological chemistry · 2013Article
- Prolonged injury and altered lung function after ozone inhalation in mice with chronic lung inflammation.American journal of respiratory cell and molecular biology · 2012Article
- Acute mechanical forces cause deterioration in lung structure and function in elastase-induced emphysema.American journal of physiology. Lung cellular and molecular physiology · 2012Article
- Effects of maternal food restriction on offspring lung extracellular matrix deposition and long term pulmonary function in an experimental rat model.Pediatric pulmonology · 2012Article
- Longitudinal study of spatially heterogeneous emphysema progression in current smokers with chronic obstructive pulmonary disease.PloS one · 2012Article
- Structure-function relations in an elastase-induced mouse model of emphysema.American journal of respiratory cell and molecular biology · 2011Article
- Lung parenchymal mechanics.Comprehensive Physiology · 2011Review
- Emergent behavior of regional heterogeneity in the lung and its effects on respiratory impedance.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Review
- Linking microscopic spatial patterns of tissue destruction in emphysema to macroscopic decline in stiffness using a 3D computational model.PLoS computational biology · 2011Article
- Emergent structure-function relations in emphysema and asthma.Critical reviews in biomedical engineering · 2011Review
- Recent advances and new opportunities in lung mechanobiology.Journal of biomechanics · 2010Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The nature of the development of emphysema in the tight skin (Tsk) and the pallid (Pa) mice are not well understood. We assessed the mechanical and nonlinear properties of the respiratory system, the alveolar structure, and the levels of microfibril-associated glycoproteins (MAGP) 1 and 2 in Tsk mice with developmental emphysema; in Pa mice, which are thought to develop adult onset emphysema; and their background, the C57BL/6 mice, at an age of 7 wk. Minor differences between collagen-related elastic properties of the lungs of the Pa and C57BL/6 mice were seen at this early age. The lungs of the Tsk mice were significantly softer yet more nonlinear than those of the Pa and C57BL/6 mice. The MAGP-1 levels were similar in all three groups. However, the level of MAGP-2, which is associated with both fibrillin-1 and collagen, was higher in the Tsk than in the Pa mice, which also had more MAGP-2 than the C57BL/6. Both the mean and the variance of alveolar diameters were larger in the Tsk than in the other two groups, while the variance in the Pa was larger than in the C57BL/6 mice, implying early development of heterogeneity. Using a network model of the parenchyma, we linked the pathophysiologic changes in the Tsk mice to mechanical forces and failure of the alveolar walls. Our findings suggest the possibility that MAGP-2-related abnormal collagen assembly, combined with mechanical forces, is involved in the progression of emphysema in the Tsk mice.
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