ArticleWorld journal of gastroenterology2005
Increased susceptibility of ethanol-treated gastric mucosa to naproxen and its inhibition by DA-9601, an Artemisia asiatica extract.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
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- Humulene Inhibits Acute Gastric Mucosal Injury by Enhancing Mucosal Integrity.Antioxidants (Basel, Switzerland) · 2021Article
- Gastroprotective Effects of Inulae Flos on HCl/Ethanol-Induced Gastric Ulcers in Rats.Molecules (Basel, Switzerland) · 2020Article
- Protective Effect ofInternational journal of molecular sciences · 2018Article
- Anticancer effect of eupatilin on glioma cells through inhibition of the Notch-1 signaling pathway.Molecular medicine reports · 2016Article
- In vivo gastric residence and gastroprotective effect of floating gastroretentive tablet of DA-9601, an extract of Artemisia asiatica, in beagle dogs.Drug design, development and therapy · 2016Article
- Eupatilin ameliorates collagen induced arthritis.Journal of Korean medical science · 2015Article
- Protective Effect of Artemisia asiatica Extract and Its Active Compound Eupatilin against Cisplatin-Induced Renal Damage.Evidence-based complementary and alternative medicine : eCAM · 2015Article
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- Protective Effect of Flos Lonicerae against Experimental Gastric Ulcers in Rats: Mechanisms of Antioxidant and Anti-Inflammatory Action.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- The globalization of traditional medicine in northern peru: from shamanism to molecules.Evidence-based complementary and alternative medicine : eCAM · 2013Review
- Prickly pear cactus (Opuntia ficus indica var. saboten) protects against stress-induced acute gastric lesions in rats.Journal of medicinal food · 2012Article
- Accelerated Ulcer Healing and Resistance to Ulcer Recurrence with Gastroprotectants in Rat Model of Acetic Acid-induced Gastric Ulcer.Journal of clinical biochemistry and nutrition · 2008Article
- Accumulation of topical naproxen by cultured oral epithelium.Journal of dental research · 2007Article
- Effect of different cyclooxygenase inhibitors on gastric adaptive cytoprotection induced by 20% ethanol.Digestive diseases and sciences · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo examine the effect of DA-9601, a new gastroprotective agent, on the vulnerability of ethanol-treated rat's stomach to naproxen (NAP).
methodsMale Sprague-Dawley rats were pretreated with 1 mL of 50% ethanol twice a day for 5 d and then NAP (50 mg/kg) was administered. DA-9601 was administered 1 h before NAP. Four hours after NAP, the rats were killed to examine gross injury index (mm2), histologic change and to determine mucosal levels of malondialdehyde (MDA), prostaglandin E2 (PGE2), glutathione (GSH) and myeloperoxidase (MPO).
resultsPretreatment of ethanol significantly increased NAP-induced gastric lesions, as well as an increase in MDA and MPO. On the contrary, mucosal PGE2 and GSH contents were decreased dramatically by ethanol pretreatment, which were aggravated by NAP. DA-9601 significantly reduced NAP-induced gastric injury grossly and microscopically, regardless of pretreatment with ethanol. DA-9601 preserved, or rather, increased mucosal PGE2 and GSH in NAP-treated rats (P<0.05), with reduction in mucosal MDA and MPO levels.
conclusionThese results suggest that repeated alcohol consumption renders gastric mucosa more susceptible to NSAIDs though, at least in part, reduction of endogenous cytoprotectants including PGE2 and GSH, and increase in MPO activation, and that DA-9601, a new gastroprotectant, can reduce the increased vulnerability of ethanol consumers to NSAIDs-induced gastric damage via the mechanism in which PGE2 and GSH are involved.
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