ArticleWorld journal of gastroenterology2005
Possible involvement of leptin and leptin receptor in developing gastric adenocarcinoma.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- Plasma VEGF and Leptin Values in Patients With Gastric Intestinal Metaplasia and Metabolic Syndrome.Frontiers in oncology · 2022Article
- Insulin Resistance and Cancer: In Search for a Causal Link.International journal of molecular sciences · 2021Review
- Assessment of expression levels of leptin and leptin receptor as potential biomarkers for risk of prostate cancer development and aggressiveness.Cancer medicine · 2020Article
- Role of Obesity in the Tumorigenesis of Gastric Cancer.International journal of preventive medicine · 2020Review
- Gastric Leptin and Tumorigenesis: Beyond Obesity.International journal of molecular sciences · 2019Review
- Leptin signaling and cancer chemoresistance: Perspectives.World journal of clinical oncology · 2017Article
- Leptin receptor signaling is required for high-fat diet-induced atrophic gastritis in mice.Nutrition & metabolism · 2016Article
- Esophageal adenocarcinoma and obesity: peritumoral adipose tissue plays a role in lymph node invasion.Oncotarget · 2015Article
- Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice.Oncogene · 2014Article
- Recombinant human leptin induces growth inhibition and apoptosis in human gastric cancer MGC-803 cells.Clinical and experimental medicine · 2013Article
- Susceptibility of gastric cancer according to leptin and leptin receptor gene polymorphisms in Korea.Journal of the Korean Surgical Society · 2012Article
- Leptin regulates proliferation and apoptosis in human prostate.TheScientificWorldJournal · 2012Article
- Expression and clinical significance of leptin, the functional receptor of leptin (OB-Rb) and HER-2 in non-small-cell lung cancer: a retrospective analysis.Journal of cancer research and clinical oncology · 2011Article
- Overexpression of the obesity hormone leptin in human colorectal cancer.Journal of clinical pathology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the expression of leptin and leptin receptor (ob-R) in intestinal-type gastric cancer and precancerous lesions, and to explore the possible mechanism and role of the leptin system in developing intestinal-type gastric adenocarcinoma.
methodsImmunohistochemistry was performed to examine the expression of leptin and leptin receptor in archival samples of gastric adenocarcinoma and preneoplastic lesions, including intestinal metaplasia and mild to severe gastric epithelial dysplasia. Positive staining was identified and percentage of positive staining was graded.
resultsDual expression of leptin and leptin receptor were detected in 80% (16/20) intestinal metaplasia, 86.3% (25/30) mild gastric epithelial dysplasia, 86.7% (26/30) moderate gastric epithelial dysplasia, 93.3% (28/30) severe gastric epithelial dysplasia, 91.3% (55/60) intestinal-type gastric adenocarcinoma and 30.0% (9/30) diffuse-type gastric carcinoma. The percentage of dual expression of leptin and leptin receptor in intestinal-type gastric adenocarcinoma was significantly higher than that in diffuse-type gastric adenocarcinoma (c2 = 37.022, P<0.01).
conclusionOur results indicate the presence of an autocrine loop of leptin system in the development of intestinal-type gastric adenocarcinoma.
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