SynthesisWorld journal of gastroenterology2005
Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous clearance of hepatitis C virus infection: a meta-analysis.
Synthesis in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Human leukocyte antigen pharmacogenetics in infectious diseases: anti-infective drug toxicity and host immune response.Frontiers in pharmacology · 2026Review
- Hepatitis C virus-associated cardiomyopathy: A review of pathogenesis.World journal of virology · 2025Article
- Contemporary Insights into Hepatitis C Virus: A Comprehensive Review.Microorganisms · 2024Review
- Frequency of the Main Human Leukocyte Antigen A, B, DR, and DQ Loci Known to Be Associated with the Clearance or Persistence of Hepatitis C Virus Infection in a Healthy Population from the Southern Region of Morocco: A Preliminary Study.Diseases (Basel, Switzerland) · 2024Article
- The relationship between COVID-19 and HLA in kidney transplant recipients, an evaluation of predictive and prognostic factors.Clinical transplantation · 2022Article
- Association betweenBMJ open · 2018Article
- The antigenic variability of HCV in viral HLA-Ag binding is related to the activation of the host immune response.Scientific reports · 2017Article
- Influence of IFNL3 and HLA-DPB1 genotype on postpartum control of hepatitis C virus replication and T-cell recovery.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The Associations of HLA-A*02:01 and DRB1*11:01 with Hepatitis C Virus Spontaneous Clearance Are Independent of IL28B in the Chinese Population.Scientific reports · 2016Article
- Association between theBiomedical reports · 2016Article
- Human Leukocyte Antigen Class II Alleles Are Associated with Hepatitis C Virus Natural Susceptibility in the Chinese Population.International journal of molecular sciences · 2015Article
- Article
- Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection.Gut · 2015Article
- IL28B gene polymorphisms in mono- and HIV-coinfected chronic hepatitis C patients.Frontiers in microbiology · 2015Article
- Prediction of T-cell epitopes of hepatitis C virus genotype 5a.Virology journal · 2014Article
- HLA class II associated with outcomes of hepatitis B and C infections.World journal of gastroenterology · 2013Article
- Human leukocyte antigen class II alleles (DQB1 and DRB1) as predictors for response to interferon therapy in HCV genotype 4.Mediators of inflammation · 2013Article
- Theoretical basis of a beneficial role for vitamin D in viral hepatitis.World journal of gastroenterology · 2012Review
- Article
- HLA and infectious diseases.Clinical microbiology reviews · 2009Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess the associations of human leukocyte antigen (HLA) class II DQB1*0301 and/or DRB1*1101 allele with spontaneous hepatitis C virus (HCV) clearance by meta-analysis of individual dataset from all studies published till date.
methodsTo clarify the impact of HLA class II polymorphisms on viral clearance, we performed a meta-analysis of the published data from 11 studies comparing the frequencies of DQB1*0301 and DRB1*1101 alleles in individuals with spontaneous resolution to those with persistent infection. As we identified the heterogeneity between studies, summary statistical data were calculated based on a random-effect model.
resultsMeta-analyses yielded summary estimates-odds ratio (OR) of 2.36 [95%CI (1.62, 3.43), P<0.00001] and 2.02 [95%CI (1.56, 2.62), P<0.00001] for the effects of DQB1*0301 and DRB1*1101 alleles on spontaneous clearance of HCV, respectively.
conclusionThese results support the hypothesis that specific HLA class II alleles might influence the susceptibility or resistance to persistent HCV infection. Both DQB1*0301 and DRB1*1101 are protective alleles and present HCV epitopes more effectively to CD4(+)T lymphocytes than others, and subjects with these two alleles are at a lower risk of developing chronic HCV infection. Large, multi-ethnic confirmatory and well-designed studies are needed to determine the host genetic determinants of HCV infection.
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