ArticleWorld journal of gastroenterology2005
Etiology and functional status of liver cirrhosis by 31P MR spectroscopy.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 48 citations in OpenAlex.
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- Absolute Quantification of Phosphor-Containing Metabolites in the Liver UsingJournal of magnetic resonance imaging : JMRI · 2019Article
- Contributions of Magnetic Resonance Imaging to Gastroenterological Practice: MRIs for GIs.Digestive diseases and sciences · 2018Article
- Progress in non-invasive detection of liver fibrosis.Cancer biology & medicine · 2018Article
- Phosphodiester content measured in human liver by in vivoMagnetic resonance in medicine · 2017Article
- In-vivoAnalytical biochemistry · 2017Review
- Measuring short-term liver metabolism non-invasively: postprandial and post-exercise ¹H and ³¹P MR spectroscopy.Magma (New York, N.Y.) · 2015Article
- Article
- Application of localized ³¹P MRS saturation transfer at 7 T for measurement of ATP metabolism in the liver: reproducibility and initial clinical application in patients with non-alcoholic fatty liver disease.European radiology · 2014Article
- Noninvasive diagnosis of cirrhosis: a review of different imaging modalities.World journal of gastroenterology · 2014Review
- A comparison of MR elastography and 31P MR spectroscopy with histological staging of liver fibrosis.European radiology · 2012Article
- Magnetic resonance spectroscopy to study hepatic metabolism in diffuse liver diseases, diabetes and cancer.World journal of gastroenterology · 2010Review
- Parametric exploration of the liver by magnetic resonance methods.European radiology · 2009Article
- Biochemical metabolic changes assessed by 31P magnetic resonance spectroscopy after radiation-induced hepatic injury in rabbits.World journal of gastroenterology · 2009Article
- Transient elastography for the assessment of chronic liver disease: ready for the clinic?World journal of gastroenterology · 2007Review
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo assess the functional status and etiology of liver cirrhosis by quantitative (31)P magnetic resonance spectroscopy (MRS).
methodsA total of 80 patients with liver cirrhosis of different etiology and functional status described by Child-Pugh score were examined and compared to 11 healthy volunteers. MR examination was performed on a 1.5 T imager using a (1)H/(31)P surface coil by the 2D chemical shift imaging technique. Absolute concentrations of phosphomonoesters (PME), phosphodiesters (PDE), inorganic phosphate (Pi) and adenosine triphosphate (ATP) were measured.
resultsMRS changes reflected the degree of liver dysfunction in all the patients as well as in individual etiological groups. The most important change was a decrease of PDE. It was possible to distinguish alcoholic, viral and cholestatic etiologies based on MR spectra. Alcoholic and viral etiology differed in PDE (alcoholic, viral, controls: 6.5+/-2.3, 6.5+/-3.1, 10.8+/-2.7 mmol/L, P<0.001) and ATP (alcoholic, viral, controls: 2.9+/-0.8, 2.8+/-0.9, 3.7+/-1.0 mmol/L, P<0.01) from the control group. Unlike viral etiology, patients with alcoholic etiology also differed in Pi (alcoholic, controls: 1.2+/-0.4, 1.6+/-0.6 mmol/L, P<0.05) from controls. No significant changes were found in patients with cholestatic disease and controls; nevertheless, this group differed from both alcoholic and viral groups (cholestatic, alcoholic, viral: 9.4+/-2.7, 6.5+/-2.3, 6.5+/-3.1 mmol/L, P<0.005) in PDE.
conclusion(31)P MRS can significantly help in non-invasive separation of different etiological groups leading to liver cirrhosis. In addition, MRS changes reflect functional liver injury.
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