ArticleIntensive care medicine2006
Elevation in interleukin 13 levels in patients diagnosed with systemic inflammatory response syndrome.
Article in Intensive care medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Soluble interleukin-13rα1: a circulating regulator of glucose.American journal of physiology. Endocrinology and metabolism · 2017Trial
- Exploring the Role of Hormones and Cytokines in Osteoporosis Development.Biomedicines · 2024Review
- Traumatic inflammatory response: pathophysiological role and clinical value of cytokines.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Review
- Clinical chorioamnionitis at term V: umbilical cord plasma cytokine profile in the context of a systemic maternal inflammatory response.Journal of perinatal medicine · 2016Article
- Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients.International journal of inflammation · 2015Article
- Childhood chronic physical aggression associates with adult cytokine levels in plasma.PloS one · 2013Article
- Cytokines in the systemic inflammatory response syndrome: a review.HSR proceedings in intensive care & cardiovascular anesthesia · 2010Article
- Diurnal variation of melatonin and cortisol is maintained in non-septic intensive care patients.Intensive care medicine · 2009Article
- Year in review in Intensive Care Medicine, 2006. I. Experimental studies. Clinical studies: brain injury, renal failure and endocrinology.Intensive care medicine · 2007Review
- Low serum interleukin-13 levels correlate with poorer prognoses for colorectal cancer patients.International surgeryArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine plasma levels and circadian rhythm of interleukin 13 (IL-13), tumour necrosis factor (TNF) alpha and total serum cortisol in the systemic inflammatory response syndrome (SIRS). DESIGN AND
settingProspective observational study in a 12-bed medical-surgical ICU of a 500-bed university hospital. PATIENTS: Ten patients with SIRS and eight controls. MEASUREMENTS: Arterial blood was sampled hourly for 24 h for measurement of plasma IL-13, TNF- alpha, cortisol and white blood cell count (WCC) differential within 24 h of development of SIRS.
resultsThere were significantly higher plasma IL-13 levels in SIRS patients than in controls (1282 vs. 713 pg/ml). IL-13 was significantly higher in patients with a diagnosis of sepsis than in those with non-infectious causes of SIRS (2080 vs. 515 pg/ml). In SIRS the elevation in IL-13 was associated with higher TNF-alpha and reduced WCC. A circadian rhythm was observed in plasma IL-13 secretion. No distinct circadian rhythm was noted for TNF- alpha, and the normal circadian rhythm of serum cortisol was lost.
conclusionsThe anti-inflammatory cytokine IL-13 is elevated in early SIRS. Its plasma level exhibits a circadian rhythm and may be modulated in part by TNF-alpha. SIRS patients have disruption of the normal circadian rhythm of serum cortisol.
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