ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2006
Features of the metabolic syndrome and the risk of non-vertebral fractures: the Tromsø study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers, 5 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 5 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- The interplay between circulating high-density lipoprotein, age and fracture risk: a new cohort study and systematic meta-analysis.GeroScience · 2023Pooled it
- Does metabolic syndrome increase the risk of fracture? A systematic review and meta-analysis.Archives of osteoporosis · 2022Pooled it
- The relationship between subclinical thyroid dysfunction and the risk of fracture or low bone mineral density: a systematic review and meta-analysis of cohort studies.Journal of bone and mineral metabolism · 2018Pooled it
- Subclinical thyroid dysfunction and the risk for fractures: a systematic review and meta-analysis.Annals of internal medicine · 2014Pooled it
- The association between metabolic syndrome and bone mineral density: a meta-analysis.Endocrine · 2012Pooled it
- Efficacy and Safety of Risedronate in Osteoporosis Subjects with Comorbid Diabetes, Hypertension, and/or Dyslipidemia: A Post Hoc Analysis of Phase III Trials Conducted in Japan.Calcified tissue international · 2016Trial
- Bone Health in Metabolic Syndrome-Is It a Neglected Aspect of Dysmetabolic-Related Diseases?Journal of clinical medicine · 2025Review
- Fracture Risk Assessment in Metabolic Syndrome in Terms of Secondary Osteoporosis Potential. A Narrative Review.Calcified tissue international · 2025Review
- Impact of metabolic syndrome on bone mineral density in men over 50 and postmenopausal women according to U.S. survey results.Scientific reports · 2024Article
- Waist circumference, among metabolic syndrome components, predicts degraded trabecular bone score: a retrospective study of a female population from the 2005-2008 NHANES cohorts.Frontiers in endocrinology · 2024Article
- Risk Factors for Chronic Non-Communicable Diseases and Osteoporotic Fractures in a Middle and Elderly-Aged Population.Journal of personalized medicine · 2022Article
- The Association of Lipids and Lipoproteins with Hip Fracture Risk: The Cardiovascular Health Study.The American journal of medicine · 2022Article
- Major osteoporosis fracture prediction in type 2 diabetes: a derivation and comparison study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Prevalence and Risk Factors of Osteoporosis in Patients with Type 2 Diabetes Mellitus in Nanchang (China): A Retrospective Cohort Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- The importance of the UGT1A1 variants in the development of osteopenia and osteoporosis in postmenopausal women.Scientific reports · 2021Article
- Metabolic factors and hip fracture risk in a large Austrian cohort study.Bone reports · 2020Article
- Relationship Between Metabolic Syndrome and Bone Health - An Evaluation of Epidemiological Studies and Mechanisms Involved.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Type 2 Diabetes in Relation to Hip Bone Density, Area, and Bone Turnover in Swedish Men and Women: A Cross-Sectional Study.Calcified tissue international · 2018Article
- Association between Bone Mineral Density and Albuminuria: Cross-Sectional Analysis of Data from the 2011 Korea National Health and Nutrition Examination Survey V-2.Endocrinology and metabolism (Seoul, Korea) · 2018Article
- Association between metabolic syndrome and bone fracture risk: A community-based study using a fracture risk assessment tool.Medicine · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionWe wanted to examine whether the features of the metabolic syndrome carried an increased risk of non-vertebral fracture.
methodsThis is a population-based, 6-year follow-up of 27,159 subjects from the municipality of Tromsø, followed from 1994 until 2001. Age range was 25-98 years. Non-fasting serum levels of high-density lipoprotein (HDL), triglycerides and glucose, blood pressure (BP), weight and height were measured at baseline. All non-vertebral fractures were registered by computerised search in radiographic archives.
resultsA total of 1,249 non-vertebral fractures were registered. Increasing number of metabolic syndrome features was associated with significantly reduced fracture risk in both men and women, p= 0.004 and p<0.0001, respectively. High BP was protective against fracture in men [relative risk (RR) 0.89; 95% confidence interval (CI) 0.8-0.99)] while increased body mass index (BMI) was protective in women (RR 0.91; 95% CI 0.84-0.98). Increasing non-fasting serum levels of HDL increased fracture risk in women (RR 1.12; 95% CI 1.05-1.21). BMI modified the effect of HDL in men. Accordingly, high HDL increased fracture risk in men with high BMI (RR 1.51; 95% CI 1.2-1.9).
conclusionsIncreasing burden of metabolic syndrome features protects against non-vertebral fractures. Reduced non-vertebral fracture risk was associated with high BP in men and increased body mass in women. Lower non-fasting serum levels of HDL protect against fractures in women and obese men.
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