ArticleJournal of human hypertension2006
Mild hyperhomocysteinaemia is associated with increased aortic stiffness in general population.
Article in Journal of human hypertension, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Diabetic Nephropathy and Gaseous Modulators.Antioxidants (Basel, Switzerland) · 2023Review
- Association between Homocysteine Levels and Psoriasis: A Meta-Analysis.Annals of dermatology · 2019Article
- Hydrogen Sulfide: A Therapeutic Option in Systemic Sclerosis.International journal of molecular sciences · 2018Review
- Association between serum total homocysteine and arterial stiffness in adults: a community-based study.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Plasma Homocysteine is a Predictive Factor for Arterial Stiffness: A Community-Based 4.8-Year Prospective Study.Journal of clinical hypertension (Greenwich, Conn.) · 2015Article
- Hyperhomocysteinemia accelerates collagen accumulation in the adventitia of balloon-injured rat carotid arteries via angiotensin II type 1 receptor.International journal of molecular sciences · 2014Article
- Association between serum homocysteine and arterial stiffness in elderly: a community-based study.Journal of geriatric cardiology : JGC · 2014Article
- Micronutrient intake and status in Central and Eastern Europe compared with other European countries, results from the EURRECA network.Public health nutrition · 2013Review
- Article
- Homocysteine to hydrogen sulfide or hypertension.Cell biochemistry and biophysics · 2010Review
- Arterial stiffness: beyond pulse wave velocity and its measurement.Journal of human hypertension · 2008Article
- The velocity of the arterial pulse wave: a viscous-fluid shock wave in an elastic tube.Theoretical biology & medical modelling · 2008Article
- Synergistic effect of angiotensin II type 1 receptor and endothelial nitric oxide synthase gene polymorphisms on arterial stiffness.Journal of human hypertension · 2008Article
- Circulating homocysteine and large arterial stiffness and thickness in a population-based sample of middle-aged and elderly men.Journal of human hypertension · 2007Article
- Towards understanding the aetiology and pathophysiology of human hypertension: where are we now?Journal of human hypertension · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Total homocysteine (tHcy) level was identified as a strong and independent predictor of cardiovascular events. We investigated the association between tHcy and mechanical properties of large arteries in a random, general population-based sample of 251 subjects (mean age 48 years). Large artery properties, such as aortic and peripheral (lower-limb) pulse wave velocity (PWV), and augmentation index of radial artery were measured using semi-automatic Sphygmocor device. Aortic PWV (APWV) positively correlated with tHcy (r = 0.28, P<0.0001), and a significant increasing trend of APWV was found by tHcy quartiles (P = 0.0003 by ANOVA). This association remained significant after adjustment for conventional cardiovascular risk factors (age, gender, smoking, overweight, hypertension, dyslipidaemia and impaired glucose metabolism) and for usual homocysteine confounders (folate, B12, renal function). Subjects with mild hyperhomocysteinaemia (i.e. with tHcy > or = 15 micromol/l) had 2.74 times higher risk of having their APWV over 8.42 m/s (i.e. in the top quartile). No such association was found either for PWV measured at lower extremity or for radial augmentation index. In conclusion, in our series of subjects from general population, we found a strong and independent relationship between homocysteine concentration and APWV, a parameter of stiffness of central arteries.
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