ArticleGenes and immunity2006
Variation in the type I interferon gene cluster on 9p21 influences susceptibility to asthma and atopy.
Article in Genes and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.The Journal of allergy and clinical immunology · 2013Pooled it
- The immunogenetics of COVID-19.Immunogenetics · 2023Review
- Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections.Nature communications · 2017Article
- Article
- Article
- Expression profiles of human interferon-alpha and interferon-lambda subtypes are ligand- and cell-dependent.Immunology and cell biology · 2012Article
- Differential regulation of human interferon A gene expression by interferon regulatory factors 3 and 7.Molecular and cellular biology · 2009Article
- Interferon-lambda1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro.Immunology · 2008Article
- Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.American journal of respiratory and critical care medicine · 2007Article
- Sex-specific genetic architecture of asthma-associated quantitative trait loci in a founder population.Current allergy and asthma reports · 2006Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
A genome-wide screen for asthma and atopy susceptibility alleles conducted in the Hutterites, a founder population of European descent, reported evidence of linkage with a short tandem repeat polymorphism (STRP) within the type I interferon (IFN) gene cluster on chromosome 9p21. The goal of this study was to identify variation within the IFN gene cluster that influences susceptibility to asthma and atopic phenotypes. We screened approximately 25 kb of sequence, including the flanking sequence of all 15 functional genes and the single coding exon in 12, in Hutterites representing different IFNA-STRP genotypes. We identified 78 polymorphisms, and genotyped 40 of these (in 14 genes) in a large Hutterite pedigree. Modest associations (0.003<P<0.05) with asthma, bronchial hyper-responsiveness (BHR), and atopy were observed with individual variants or genes, spanning the entire 400 kb region. However, pairwise combinations of haplotypes between genes showed highly significant associations with different phenotypes (P<10(-5)) that were localized to specific pairs of genes or regions of this cluster. These results suggest that variation in multiple genes in the type I IFN cluster on 9p22 contribute to asthma and atopy susceptibility, and that not all genes contribute equally to all phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.