Evidence map›Paper›PMID 16436741›Full record

ArticleAntimicrobial agents and chemotherapy2006

Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes.

Klaudia Kosowska-Shick, Catherine Clark, Kim Credito, Pamela McGhee, Bonifacio Dewasse, Tatiana Bogdanovich, Peter C Appelbaum

Abstract readComparative Study
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Antimicrobial agents and chemotherapy · 2020
    Article
  5. Article
  6. Article
  7. Article
  8. Antibiotic Resistance and the MRSA Problem.Microbiology spectrum · 2019
    Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
  14. Article
  15. Article
  16. Antimicrobial agents and chemotherapy · 2013
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Klaudia Kosowska-ShickDepartment of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
Catherine Clark
Kim Credito
Pamela McGhee
Bonifacio Dewasse
Tatiana Bogdanovich
Peter C Appelbaum

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all Staphylococcus aureus strains and three Streptococcus pyogenes strains which yielded resistant clones. Retapamulin has a low potential for resistance selection in S. pyogenes, with a slow and gradual propensity for resistance development in S. aureus.

Indexed as

Amino Acid SequenceAnti-Bacterial AgentsBridged Bicyclo Compounds, HeterocyclicDiterpenesDrug Resistance, BacterialMicrobial Sensitivity TestsMolecular Sequence DataMutationProtein Synthesis InhibitorsRibosomal Protein L3Ribosomal ProteinsStaphylococcus aureusStreptococcus pyogenesAnti-Bacterial AgentsBridged Bicyclo Compounds, HeterocyclicDiterpenesProtein Synthesis InhibitorsretapamulinRibosomal Protein L3Ribosomal Proteins

Identifiers

PMID16436741
PMCPMC1366917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.