ArticleAntimicrobial agents and chemotherapy2006
Antibacterial properties of dermaseptin S4 derivatives under extreme incubation conditions.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Pathogenic Bacterial Detection Using Vertical-Capacitance Sensor Array Immobilized with the Antimicrobial Peptide Melittin.Sensors (Basel, Switzerland) · 2024Article
- The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions.Chemical Society reviews · 2021Review
- Short Ligand, Cysteine-Modified Warnericin RK Antimicrobial Peptides Favor Highly Sensitive Detection ofACS omega · 2021Article
- In silico identification and functional validation of linear cationic α-helical antimicrobial peptides in the ascidian Ciona intestinalis.Scientific reports · 2020Article
- Dermaseptins, Multifunctional Antimicrobial Peptides: A Review of Their Pharmacology, Effectivity, Mechanism of Action, and Possible Future Directions.Frontiers in pharmacology · 2019Review
- Chemical and Biological Sensors for Food-Quality Monitoring and Smart Packaging.Foods (Basel, Switzerland) · 2018Review
- Multifunctional Nanotechnology-Enabled Sensors for Rapid Capture and Detection of Pathogens.Sensors (Basel, Switzerland) · 2017Review
- Application of immobilized synthetic anti-lipopolysaccharide peptides for the isolation and detection of bacteria.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Structure-activity relationship of synthetic variants of the milk-derived antimicrobial peptide αs2-casein f(183-207).Applied and environmental microbiology · 2013Article
- Boosting salt resistance of short antimicrobial peptides.Antimicrobial agents and chemotherapy · 2013Article
- Easy strategy to increase salt resistance of antimicrobial peptides.Antimicrobial agents and chemotherapy · 2011Article
- Mechanisms mediating bactericidal properties and conditions that enhance the potency of a broad-spectrum oligo-acyl-lysyl.Antimicrobial agents and chemotherapy · 2011Article
- Electrical detection of pathogenic bacteria via immobilized antimicrobial peptides.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Experimental conditions that enhance potency of an antibacterial oligo-acyl-lysyl.Antimicrobial agents and chemotherapy · 2010Article
- Novel expression vector for secretion of cecropin AD in Bacillus subtilis with enhanced antimicrobial activity.Antimicrobial agents and chemotherapy · 2009Article
- Antibacterial properties and mode of action of a short acyl-lysyl oligomer.Antimicrobial agents and chemotherapy · 2009Article
- Dermaseptins and magainins: antimicrobial peptides from frogs' skin-new sources for a promising spermicides microbicides-a mini review.Journal of biomedicine & biotechnology · 2009Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibacterial properties of the frog-derived peptide dermaseptin S4 and a series of synthetic derivatives against the food pathogen Escherichia coli O157:H7 were investigated under extreme incubation conditions. The 28-mer analog K4K20S4 (P28) displayed an MIC of 8 microM and rapid bactericidal kinetics under standard culture conditions. Potent bactericidal properties were maintained at high salt concentrations, under acidic or basic conditions, and at extreme temperatures. The N-terminal 14-mer sequence (P14) displayed higher potency (MIC, 4 microM) but only within a narrow range of incubation conditions, pointing to the importance of the C-terminal domain of P28. The potency range was reextended upon conjugation of aminododecanoic acid to P14. The resulting lipopeptide was even more potent (MIC, 2 microM) and affected bacterial viability under most of the conditions tested, including in commercial apple juice. The mechanistic implications of peptides' hydrophobicity, charge, structure, and binding to an idealized membrane were probed and are discussed here. Collectively, the data indicate interest in simple peptide-based compounds for design of antimicrobials that affect pathogens under a variable range of incubation conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.