ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Medullary raphe neurons facilitate brown adipose tissue activation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Sympathetic innervation of the supraclavicular brown adipose tissue: A detailed anatomical study.PloS one · 2023Article
- 5-HT Receptors and Temperature Homeostasis.Biomolecules · 2021Review
- Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.Redox biology · 2017Review
- Prolonged stimulation of a brainstem raphe region attenuates experimental autoimmune encephalomyelitis.Neuroscience · 2017Article
- Entanglement between thermoregulation and nociception in the rat: the case of morphine.Journal of neurophysiology · 2016Article
- Central neural control of thermoregulation and brown adipose tissue.Autonomic neuroscience : basic & clinical · 2016Review
- Cholinergic neurons in the dorsomedial hypothalamus regulate mouse brown adipose tissue metabolism.Molecular metabolism · 2015Article
- Central serotonergic neurons activate and recruit thermogenic brown and beige fat and regulate glucose and lipid homeostasis.Cell metabolism · 2015Article
- Role of the Oxytocin Receptor Expressed in the Rostral Medullary Raphe in Thermoregulation During Cold Conditions.Frontiers in endocrinology · 2015Article
- Central nervous system regulation of brown adipose tissue.Comprehensive Physiology · 2014Review
- Review of overlap between thermoregulation and pain modulation in fibromyalgia.The Clinical journal of pain · 2014Review
- Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression.Journal of neurophysiology · 2012Article
- Medullary circuits for nociceptive modulation.Current opinion in neurobiology · 2012Review
- Central control of brown adipose tissue thermogenesis.Frontiers in endocrinology · 2012Article
- Swim stress activates serotonergic and nonserotonergic neurons in specific subdivisions of the rat dorsal raphe nucleus in a temperature-dependent manner.Neuroscience · 2011Article
- μ-Opioid modulation in the rostral solitary nucleus and reticular formation alters taste reactivity: evidence for a suppressive effect on consummatory behavior.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Altered ventilatory and thermoregulatory control in male and female adult Pet-1 null mice.Respiratory physiology & neurobiology · 2011Article
- Central neural pathways for thermoregulation.Frontiers in bioscience (Landmark edition) · 2011Review
- Local GABAergic modulation of the activity of serotoninergic neurons in the nucleus raphe magnus.Neuroscience and behavioral physiology · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recent evidence suggests that neurons in the medullary raphe are critical to the activation of brown adipose tissue (BAT), the major source of nonshivering heat production in the rat. Yet it is unclear which medullary raphe cells participate in cold defense and how participating cells contribute to BAT activation. Therefore, we recorded extracellularly from raphe cells during three thermoregulatory challenges that evoked an increase in BAT temperature in anesthetized rats: central cold, ambient cold, or intracerebroventricular prostaglandin E2 (PGE2) injection. Physiologically identified serotonergic (p5HT) cell discharge increased in response to cold or PGE2 administration and was positively correlated with BAT temperature. However, none of the 147 physiologically identified non-serotonergic (non-p5HT) cells recorded responded to thermoregulatory challenges that evoked an increase in BAT temperature. To test for modulation of BAT activation by non-p5HT cells that are either excited (ON cells) or inhibited (OFF cells) by noxious cutaneous stimulation, noxious stimuli were applied during evoked BAT temperature increases. Noxious stimulation suppressed BAT activation, suggesting that cells inhibited by noxious stimulation facilitate spinal circuits controlling BAT. To test whether medullary OFF cells modulate BAT activity, the mu-opiate receptor agonist (d-Ala2, N-Me-Phe4, Gly-ol5)-enkephalin (DAMGO) was microinjected into the raphe magnus, a manipulation that selectively activates OFF cells. DAMGO microinjection blocked noxious stimulation-evoked suppression of PGE2-induced BAT temperature increases. Thus, both p5HT and non-p5HT OFF cells in the medullary raphe facilitate BAT activation in response to cold challenge or pyrogen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.