ArticleMolecular biology of the cell2006
Activity- and calcineurin-independent nuclear shuttling of NFATc1, but not NFATc3, in adult skeletal muscle fibers.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Identifying regulators of aged fibroblast activation in 3D tissue models.Scientific reports · 2025Article
- Calcineurin in the heart: New horizons for an old friend.Cellular signalling · 2021Review
- Amniotic membrane matrix effects on calcineurin-NFAT-related gene expressions of SHED treated with VEGF for endothelial differentiation.In vitro cellular & developmental biology. Animal · 2021Article
- Calmodulin-Binding Proteins in Muscle: A Minireview on Nuclear Receptor Interacting Protein, Neurogranin, and Growth-Associated Protein 43.International journal of molecular sciences · 2020Review
- Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus.Molecular microbiology · 2019Article
- Calcineurin signaling in the heart: The importance of time and place.Journal of molecular and cellular cardiology · 2017Review
- Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis.Molecular cancer · 2014Review
- Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons.The Journal of biological chemistry · 2012Article
- Kinetics of nuclear-cytoplasmic translocation of Foxo1 and Foxo3A in adult skeletal muscle fibers.American journal of physiology. Cell physiology · 2012Article
- Nitric oxide synthase inhibition prevents activity-induced calcineurin-NFATc1 signalling and fast-to-slow skeletal muscle fibre type conversions.The Journal of physiology · 2012Article
- Localization and regulation of the N terminal splice variant of PGC-1α in adult skeletal muscle fibers.Journal of biomedicine & biotechnology · 2012Article
- Nuclear presence of nuclear factor of activated T cells (NFAT) c3 and c4 is required for Toll-like receptor-activated innate inflammatory response of monocytes/macrophages.Cellular signalling · 2011Article
- Excitation-transcription coupling in skeletal muscle: the molecular pathways of exercise.Biological reviews of the Cambridge Philosophical Society · 2011Review
- Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Review
- Activation of NFATc1 is directly mediated by IP3 in adult cardiac myocytes.American journal of physiology. Heart and circulatory physiology · 2010Article
- DNA binding sites target nuclear NFATc1 to heterochromatin regions in adult skeletal muscle fibers.Histochemistry and cell biology · 2010Article
- A fluorescence-based assay to monitor transcriptional activity of NFAT in living cells.The Journal of physiology · 2010Article
- Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure.American journal of physiology. Heart and circulatory physiology · 2010Article
- Therapeutic targeting of signaling pathways in muscular dystrophy.Journal of molecular medicine (Berlin, Germany) · 2010Review
- Regulation of nuclear factor of activated T cells (NFAT) in vascular endothelial cells.Journal of molecular and cellular cardiology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The transcription factor NFATc1 may be involved in slow skeletal muscle gene expression. NFATc1 translocates from cytoplasm to nuclei during slow fiber type electrical stimulation of skeletal muscle fibers because of activation of the Ca(2+)-dependent phosphatase calcineurin, resulting in nuclear factor of activated T-cells (NFAT) dephosphorylation and consequent exposure of its nuclear localization signal. Here, we find that unstimulated adult skeletal muscle fibers exhibit a previously unanticipated nucleocytoplasmic shuttling of NFATc1 without appreciable nuclear accumulation. In resting fibers, the nuclear export inhibitor leptomycin B caused nuclear accumulation of NFATc1 (but not of isoform NFATc3) and formation of NFATc1 intranuclear bodies independent of calcineurin. The rate of nuclear uptake of NFATc1 was 4.6 times lower in resting fibers exposed to leptomycin B than during electrical stimulation. Inhibitors of glycogen synthase kinase and protein kinase A or of casein kinase 1 slowed the decay of nuclear NFATc1 after electrical stimulation, but they did not cause NFATc1 nuclear uptake in unstimulated fibers. We propose that two nuclear translocation pathways, one pathway mediated by calcineurin activation and NFAT dephosphorylation and the other pathway independent of calcineurin and possibly independent of NFAT dephosphorylation, determine the distribution of NFATc1 between cytoplasm and nuclei in adult skeletal muscle.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.