ArticleBMC genomics2006
BLAST screening of chlamydial genomes to identify signature proteins that are unique for the Chlamydiales, Chlamydiaceae, Chlamydophila and Chlamydia groups of species.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
- Bacterial usurpation of the OTU deubiquitinase fold.The FEBS journal · 2024Review
- Eukaryotic Cell Permeabilisation to Identify New Putative Chlamydial Type III Secretion System Effectors Secreted within Host Cell Cytoplasm.Microorganisms · 2020Article
- Global survey of mRNA levels and decay rates ofHeliyon · 2017Article
- Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection.Cell host & microbe · 2015Article
- Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors.PloS one · 2015Article
- A path forward for the chlamydial virulence factor CPAF.Microbes and infection · 2013Review
- The core and unique proteins of haloarchaea.BMC genomics · 2012Article
- Lateral gene exchanges shape the genomes of amoeba-resisting microorganisms.Frontiers in cellular and infection microbiology · 2012Review
- Molecular Signatures for the PVC Clade (Planctomycetes, Verrucomicrobia, Chlamydiae, and Lentisphaerae) of Bacteria Provide Insights into Their Evolutionary Relationships.Frontiers in microbiology · 2012Article
- Structure and protein-protein interaction studies on Chlamydia trachomatis protein CT670 (YscO Homolog).Journal of bacteriology · 2010Article
- The chlamydial functional homolog of KsgA confers kasugamycin sensitivity to Chlamydia trachomatis and impacts bacterial fitness.BMC microbiology · 2009Article
- Signature genes as a phylogenomic tool.Molecular biology and evolution · 2008Article
- Translational genomics to develop a Salmonella enterica serovar Paratyphi A multiplex polymerase chain reaction assay.The Journal of molecular diagnostics : JMD · 2007Article
- Identification of homologs in insignificant blast hits by exploiting extrinsic gene properties.BMC bioinformatics · 2007Article
- Phylogeny and molecular signatures (conserved proteins and indels) that are specific for the Bacteroidetes and Chlorobi species.BMC evolutionary biology · 2007Article
- Phylogenomic analysis of proteins that are distinctive of Archaea and its main subgroups and the origin of methanogenesis.BMC genomics · 2007Article
- Application of the character compatibility approach to generalized molecular sequence data: branching order of the proteobacterial subdivisions.Journal of molecular evolution · 2007Article
- Molecular signatures (unique proteins and conserved indels) that are specific for the epsilon proteobacteria (Campylobacterales).BMC genomics · 2006Review
- Evidence for horizontal gene transfer betweenBacteriophageArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChlamydiae species are of much importance from a clinical viewpoint. Their diversity both in terms of their numbers as well as clinical involvement are presently believed to be significantly underestimated. The obligate intracellular nature of chlamydiae has also limited their genetic and biochemical studies. Thus, it is of importance to develop additional means for their identification and characterization.
resultsWe have carried out analyses of available chlamydiae genomes to identify sets of unique proteins that are either specific for all Chlamydiales genomes, or different Chlamydiaceae family members, or members of the Chlamydia and Chlamydophila genera, or those unique to Protochlamydia amoebophila, but which are not found in any other bacteria. In total, 59 Chlamydiales-specific proteins, 79 Chlamydiaceae-specific proteins, 20 proteins each that are specific for both Chlamydia and Chlamydophila and 445 ORFs that are Protochlamydia-specific were identified. Additionally, 33 cases of possible gene loss or lateral gene transfer were also detected.
conclusionThe identified chlamydiae-lineage specific proteins, many of which are highly conserved, provide novel biomarkers that should prove of much value in the diagnosis of these bacteria and in exploration of their prevalence and diversity. These conserved protein sequences (CPSs) also provide novel therapeutic targets for drugs that are specific for these bacteria. Lastly, functional studies on these chlamydiae or chlamydiae subgroup-specific proteins should lead to important insights into lineage-specific adaptations with regards to development, infectivity and pathogenicity.
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