ArticlePLoS biology2006
Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex.
Article in PLoS biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed, 162 citations in OpenAlex.
- Research Progress on the Major Histocompatibility Complex in Herbivores: Structure, Genetics, and Disease Resistance.Biology · 2026Review
- MHC in newts illuminates the evolutionary dynamics of complex regions in giant genomes.Genome research · 2026Article
- Compact genomic architecture of the axolotl MHC region: setting the record straight.Immunogenetics · 2025Article
- Plethora of New Marsupial Genomes Informs Our Knowledge of Marsupial MHC Class II.Genome biology and evolution · 2024Article
- Extant and extinct bilby genomes combined with Indigenous knowledge improve conservation of a unique Australian marsupial.Nature ecology & evolution · 2024Article
- Expanding the evo-devo toolkit: generation of 3D mammary tissue from diverse mammals.Development (Cambridge, England) · 2024Article
- An Ancestral Major Histocompatibility Complex Organization in Cartilaginous Fish: Reconstructing MHC Origin and Evolution.Molecular biology and evolution · 2023Article
- MHC architecture in amphibians - ancestral reconstruction, gene rearrangements and duplication patterns.Genome biology and evolution · 2023Article
- Structure and evolution of the squamate major histocompatibility complex as revealed by twoFrontiers in genetics · 2022Article
- Major histocompatibility complex genes and locus organization in the Komodo dragon (Varanus komodoensis).Immunogenetics · 2021Article
- NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers.Journal of cancer research and clinical oncology · 2021Article
- Article
- Annotation of immune genes in the extinct thylacine (Thylacinus cynocephalus).Immunogenetics · 2021Article
- Specimen-specific drift of densities defines distinct subclasses of extracellular vesicles from human whole saliva.PloS one · 2021Article
- A chromosome-scale reference genome and genome-wide genetic variations elucidate adaptation in yak.Molecular ecology resources · 2021Article
- Sequence and chromatin determinants of transcription factor binding and the establishment of cell type-specific binding patterns.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020Review
- Origin and evolution of the major histocompatibility complex class I region in eutherian mammals.Ecology and evolution · 2019Article
- Evolution of Copy Number at the MHC Varies across the Avian Tree of Life.Genome biology and evolution · 2019Article
- The Marine Mammal Class II Major Histocompatibility Complex Organization.Frontiers in immunology · 2019Article
- Generalists and Specialists: A New View of How MHC Class I Molecules Fight Infectious Pathogens.Trends in immunology · 2018Review
25 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 8 institutions in 3 countries.
Funding
Abstract
The first sequenced marsupial genome promises to reveal unparalleled insights into mammalian evolution. We have used the Monodelphis domestica (gray short-tailed opossum) sequence to construct the first map of a marsupial major histocompatibility complex (MHC). The MHC is the most gene-dense region of the mammalian genome and is critical to immunity and reproductive success. The marsupial MHC bridges the phylogenetic gap between the complex MHC of eutherian mammals and the minimal essential MHC of birds. Here we show that the opossum MHC is gene dense and complex, as in humans, but shares more organizational features with non-mammals. The Class I genes have amplified within the Class II region, resulting in a unique Class I/II region. We present a model of the organization of the MHC in ancestral mammals and its elaboration during mammalian evolution. The opossum genome, together with other extant genomes, reveals the existence of an ancestral "immune supercomplex" that contained genes of both types of natural killer receptors together with antigen processing genes and MHC genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.